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- Extension of Whole exome sequencing in LifeLines Deep & LifeLines DAG3
- Genetics of microbiome composition
- Phenotype-wide association analysis (PheWas) of established genetic risk loci of common diseases and traits
- The impact of sex chromosome loss as a clonal abnormality in otherwise healthy individuals
- Genetic nurture: how non-transmitted genes affect offspring's risk of depression and other behavioral traits
- What are the Psychological, Socioeconomic, and Genetic Factors associated with Healthy Behavior?
- Reviving early diagnosis of cardiovascular disease (RED-CVD)
- Dutch Parkinson and Microbiome Study (DUPARM)
- Unraveling the heterogeneity of Functional Somatic Symptoms
- Towards a better personalized medicine: a pathway analysis of lifestyle and environmental factors for the development of type 2 diabetes
- Sex disparities in the prescription of statins and their associations with lipid parameters: the Pharmlines Initiative
- Skin autofluorescence predicts incident type 2 diabetes, cardiovascular disease and mortality in the general population (part 2)
- Healthy behaviour and good working conditions as adaptation factors for better health and maintaining employment in workers in low SEP with a chronic disease
- Genetic association study between atopy susceptibility loci and subphenotypes of asthma and atopy
- Genome-wide association meta-analysis of traits associated with autism and investigating gene-environment correlations
- Prevalence of mood and anxiety disorders and environmental risk factors in Lifelines
- The burden of (drug-)drug-gene interactions within the Lifelines Cohort population as part of the PharmLines Initiative
- Replication of the Brainscan/UCP biomarker panel for major depressive disorder in Lifelines and investigation of the moderating effects of age and gender
- Hair cortisol in adults with Prader-Willi syndrome
- Somatic, psychosocial and lifestyle factors associated with tinnitus within the Lifelines cohort study
- The role of genetic variants in Dupuytren disease
- GWAS of commensal bacterial species from the gut microbiome
- Neighborhood influences on overweight and obesity
- Quantification and dissection of the nature-nurture question using genomic and family data
- Predictors of new onset asthma in adults
- The mediating pathways between socio-economic status and health: a life-course perspective
- Presence of auto-antibodies predicting the development of auto-immune disease in 40.000 participants of the LifeLines cohort
- SWEET: Intake of sweeteners and sweetness enhancers in relation to health and disease. A population-based approach, a HORIZON2020 project, 2018-2023
- Transgenerational determinants of socioeconomic health differences in childhood and youth
- Zorg en welbevinden onder potentiele helpers van 50-74 jaar (pilotcase)
- Aanvraag data Lifelines subjectieve en objectieve data lengte en gewicht om matig overgewicht en obesitas op geaggregeerd niveau te kunnen presenteren
- PIE=M, Physicians Implement Exercise is Medicine; The implementation of individualized active lifestyle prescription in routine clinical care
- Constructing polygenic risk predictors of psychiatric disorders
- A composite measure of gender and its association with sex, common somatic symptoms and health care seeking in the general population cohort Lifelines, part 1
- Vitamin status in low versus high socio-economic groups of the North-Netherlands LifeLines population and the phenotypes of marginal/subclinical micronutrient deficiency
- Geriatric syndromes and the risk of developing disability among older Dutch community-dwellers: differences in socio-economic position
- The role of genetic variants in Peyronie disease and its correlation with Dupuytren disease
- The human resistome and microbiome within the Dutch meat production chain, a metagenome-wide study among farmers and slaughterhouse workers
- The role of genes and exposures in COPD prevalence and incidence, lung function and lung function decline
- A genome wide association study to find novel loci associated with Heart Rate Variability
- The role of unhealthy lifestyle factors in the adverse health effects of working conditions in workers with a low SEP
- Does the Dose-dependent Association between Physical Activity and Cardiac Morbidity and Mortality Differ between Healthy Controls and Cardiovascular Disease or Cardiovascular Risk?
- Identification of genetic risk variants of non-alcoholic fatty liver disease
- DAG2plus, diepe multi-omics fenotypering van Lifelines Deep deelnemers – deel 3
- Hematopoietic phenotypes and clonal hematopoiesis in the elderly population (MDS-RIGHT - Providing the right care to the right patient with MyeloDysplastic Syndrome at the right time).
- Blood metabolomics in the DAG3 samples to understand gut microbiome-host metabolism cross-talks
- Social class and health inequalities – does capital make the difference?
- Glaucoma Genetic Risk scores within Lifelines
- Evolution of influenza specific pre-existing immunity over time
- Hypertension in living kidney donation: implications for donor screening and follow-up
- The role of immune dysregulation and metabolic syndrome on illness progression in bipolar
- Medication use in migrant and non-migrant populations in the Northern part of the Netherlands
- Detecting genetic variants associated with the variability of gene expression traits at cellular levels
- How do the Dutch sleep? An individual participant meta-analysis of sleep patterns in the Netherlands
- Spousal correlations of cardiovascular risk factors: collaborative study between Lifelines and the Tohoku Medical Megabank Orgainzation (ToMMo)
- Long-term renal effects in Dutch survivors of childhood cancer
- Studying the molecular background of extreme lipid profiles through exome sequencing in the LifeLinesDeep cohort - Extension
- Main effects of serum electrolyte concentrations on different ECG traits: a multi-cohort epidemiological analysis and GxE GWAS meta-analysis
- Microbiome, genome, and phenome associations underlying human disease
- Somatic, psychosocial and lifestyle factors associated with tinnitus within the Lifelines cohort study
- Presence of auto-antibodies and antibodies to bacterial antigens predicting the development of auto-immune disease in 40.000 participants of the Lifelines cohort
- Advanced Glycation Endproducts in depression and anxiety
- Geographical mapping of renal function and association between dietary patterns and the development and progression of chronic kidney disease (CKD)
- Eat2beNICE – Nutrition and lifestyle factors and their relation to mental health
- Impact of polyglobulia in a general population
- Heritability of glaucoma and its association with blood pressure and heart rate variability
- The genetics of Type D personality
- Does flexible work lead to more health problems (FLEXHEALTH)?
- Effect of evening screen use on sleep and health in children and adolescents
- The external exposome and the microbiome: the impact of air pollution, the urban environment, and occupational exposures on the gut microbiota in Lifelines
- Vitamin E Status in Relation to Health Problems and Complaints
- Development of risk taxation tool for SOLK in general practice
- Disentangling the genetics of depression and anxiety; add-on study in Lifelines
- Providing the right care to the right patient with MyeloDysplastic Syndrome at the right time - Part B: Exploring clonal hematopoiesis in unexplained anemia of the elderly
- Providing the right care to the right patient with MyeloDysplastic Syndrome at the right time - Part A: Exploring the relation between QoL and anemia in older individuals
- Whole exome sequencing in Lifelines Deep
- The prevalence and incidence of cancer in relation to lifestyle
- The stress hormone Cortisol and the development of Metabolic Syndrome and Cardiovascular Diseases (COMEDI study)
- Is Type D personality associated with poorer self-management?
- Associations between Common Gene Variants and Dominant Frequency during Atrial Fibrillation
- Human Reproductive Behavior meta-GWAS for the HRB consortium
- BIObanks Netherlands Internet Collaboration (BIONIC): harmonization of depression measurement for genome wide association studies
- Phenotypic characteristics of Lifelines-DAG3 participants - dataset verification DAG3
- Epidemiology of atrial fibrillation in the general Dutch population. The Lifelines cohort study.
- Development environmental and physiological risk profiles for primary open angle glaucoma for Dutch Caucasian individuals utilizing Lifelines questionnaire data information
- Role of environmental exposures and lifestyle in development and disease course of inflammatory bowel disease (IBD)
- Miscarriage, ectopic pregnancy and lipoma analysis plan
- European Meta-Analysis of Genome-Wide Association Studies of the Early Repolarization Pattern
- Providing the right care to the right patient with MyeloDysplastic Syndrome at the right time - Extension
- Lifestyle as a predictor of outcome in cancer treatment; The LifeLines from OncoLifeS participants
- A population-based analysis of the enteric microbiome, depression, and suicide
- The role of health literacy and the potential mediating function of depression in chronic kidney disease outcomes
- Collaboration between the Estonian Biobank and the Lifelines Cohort Study: Polygenic risk scores for personalized risk prediction
- Serum Electrolytes (Potassium & Sodium) Genome-Wide Association Study (GWAS)
- Genome-wide association analysis of autoimmunine hepatitis
- Interaction between genome-wide SNP data and smoking for the GIANT consortium
- GBPG SNP x AGE interaction GWAS
- Coffee Geneva Consortium GWAS
- CHARGE Age bin analysis Plan for replication in LifeLines to capture Gene-Age Interactions
- MAGIC consortium - 2 studies FBG, HbA1c
- Calculation of Variance Explained for the Global Lipids Genetics Consortium
- Lipids replication phase for IBC chip
- Social Science Genetic Association Consortium (SSGAC) GWAS on Educational Attainment
- T2D replication phase for IBC chip
- Blood Pressure replication phase for IBC chip
- Fecundity GWAS
- Unraveling Familial Colorectal Polyposis, Genetic and Genomic profiling to identify novel susceptibility genes
- GIANT - 4 studies on genetics of height, weight, BMI, waist, hip, and body fat% phenotypes
- Meta-analysis for fT4 and TSH gene replication
- Coffee consumption, snp lookup study (CHARGE consortium)
- Extreme phenotypes and other case-control analyses (GIANT)
- A new statistical method to implicate genetic variants in liver related traits
- Collaborative agreement for meta-analysis of serum urate levels; Global Urate Genetics Consortium
- GWAS Alcohol consumption
- Factors determining HbA1c: environment, lifestyle and genes
- Pilot experiment for potential whole-genome sequencing of some samples from the LifeLines cohort
- Renal Function & Microalbuminuria - GWAS
- Age at Menopause - GWAS phase
- G x E lipids GWAS phase
- Serum Albumin and Liver enzymes - GWAS phase
- Heart Rate - GWAS phase
- QT-IGC GWAS Phase
- International Consortium on Bloodpressure (ICBP) GWAS on Pulse Pressure (PP) and Mean Arterial Pressure (MAPP)
- Genome-wide studies on breast cancer and melanoma
- Genetic Origin of Dupuytren's disease and associated fibromatosis
- Vitamin D status and multimorbidity (prevalence and severity)
- Genetics of Vitamin D and active Vitamin D
- Galectin-3 and (pre-)diastolic dysfunction in the healthy elderly
- A GWAS of HDL LDL TC and TG in ~60000 samples from the CHARGE cohorts
- A note on the effect of rare variants on smoking behaviors
- A pleiotropy GWAS of BMI HDL LDL and TG
- Addendum 1 to 'The Healthy Obese Project within the BioSHaRE-EU consortium; WP5'
- Addendum 2 to 'The Healthy Obese Project within the BioSHaRE-EU consortium; WP5'
- Addendum to 'The relation between inflammatory biomarkers and gastrointestinal and general health (DAG1)'
- Age related development of auto antibodies associated with the development of multiple chronic diseases?
- Age stratified analysis of the relation between (genetic risk scores of) LDL and coronary heart disease for the CHARGE CHD consortium
- Air pollution and depression
- Albuminuria in ex-PREVEND participants
- Are depression and anxiety associated with inflammation?
- Are we betting on the wrong horse? Anxiety instead of depression as a causal risk factor for heart disease
- Association of 16 top age-at-menopause SNPs with age at menopause and menarche for the Age-at-Menopause consortium
- Association of DUSP1 SNPs with major depressive disorder
- Association of VEGF Genetic Variants with human traits
- Associations between air pollution and respiratory health in large European cohorts
- Big Data: innovative knowledge versus threats to personal integrity
- Biobanking practices: the fine art of transportation (LifeLines article about post-collection and transportation versus analysis results)
- BIObanks Netherlands Internet Collaboration (BIONIC) - BBMRI-NL regenboogproject
- Biological lifestyle social demographic and exposure factors during the female reproductive age related to healthy ageing
- Biomarkers of the bile salt homeostasis to assess CFTR activity
- Biospecimen harmonization/standardization for measures and samples required by BioSHaRE-EU - focus on inflammatory markers
- Changes of the QRS-complex and clinical outcome
- Characterization of serum antibodies and immune responses against Propionibacterium acnes (P acnes) in the sera of acne patients compared to healthy individuals
- CHARGE HDL project Replication of independent variants in the CETP locus based on a GWAS of HDL
- Chronic fatigue syndrome fibromyalgia and irritable bowel syndrome: how comparable are these functional somatic disorders?
- Chronic kidney disease and renal function: the role of socioeconomic status and genetic predisposition
- CKDGen consortium 1000 Genomes analysis plan for eGFR
- Clonal evolution of lymphoid malignancies
- Clusters of cardiovascular disease with other types of diseases related to quality of life
- Collaboration between the Estonian Biobank and the LifeLines Cohort Study: Analysis of personal genetic ancestry based on genome-wide data
- Collection of LifeLines Deep data from GoNL participants DAG2
- Combining informal care with work: A closer look on the working informal caregiver(Amendement of research proposal OV12_109)
- Comorbid Conditions of Attention deficit / hyperactive disorders (CoCA)
- Construction of a LifeLines CNV database
- Corticosteroid use in obese versus non-obese individuals
- DAG4 - Diepe fenotypering van GoNL deelnemers
- DArmGezonheidsonderzoek (DAG3)
- Data driven subtypes of depression
- Determinants and health consequences of participation in voluntary work
- Determinants of non-participation to the Dutch national breast cancer screening
- Determination of harmonized reference values of IGF-1 with respect to age and gender
- Development of non-invasive biomarkers for (sub)clinical deficiency of B-vitamins involved in sulphur metabolism relevant to healthy ageing
- Development of the food frequency questionnaire (FFQ) the “Flower FFQ” and dietary intake within Lifelines
- Developmental Coordination Disorder in the Northern Netherlands; aetiology and early precursors
- Dietary influences on mental health with ageing; cross-sectional associations in elderly and non-elderly adults in the first LifeLines wave
- Dietary intake and the food environment in the LifeLines cohort part 1
- Dietary intake and the food environment in the LifeLines cohort part 2
- Do physical activity and weight feedback loops affect body mass index?
- Dry eye disease: prevalence determinants and genetics
- Economic conditions early in life and late-life health outcomes: Analyzing the effects of job loss on morbidity and mortality at high ages and in subsequent generations
- Effects of Full Fat Dairy Products Cheese and (Minor) Milk Fat Components such as Saturated Fat and Ruminant Trans Fatty Acids on Cardiovascular Disease and Type 2 Diabetes
- Effects of road traffic noise and air pollution on diabetes and obesity in European cohorts: a harmonized approach in the BioSHaRE project
- Effects of social status and neighborhood context on major depression
- Endocrine Disrupting Chemicals and type 2 diabetes: what is their relationship?
- Environmental noise and blood pressure/heart rate
- Environmental noise and health complaints
- Eosinophil counts its genetic risk score and association with major diseases in LifeLines
- Establishing reference intervals for hemocytometry
- Estimating the geographical origin of progressive myoclonus epilepsy
- Evaluation of a diet quality score based on the Dutch Dietary Guidelines 2015 and it’s relation to cardi-metabolic health cardiovascular disease and levels of comorbidities
- Evaluation of the 2nd verification process in LifeLines
- Evaluation of the validity of the RFFT using a computerized cognitive battery (CogState) as reference standard in a population-based study (LifeLines)
- Excess risk of treatment-related health problems in breast cancer survivors
- Explaining missing obesity heritability by gene-environment interaction and pathway analysis
- Explaining regional variation in the quality of life of the elderly in North Netherlands
- Exploring the genetics of irritable bowel syndrome: the "bellygenes" initiative
- Exposure to changing living environments and its effect on health outcomes
- Exposures to brominated disinfection by-products and prospective metabolic alterations
- Fatigue in patients with chronic disease: towards a transdiagnostic risk prediction model
- Fitness fatness and disease: the influence of physical inactivity and overweight on development of chronic diseases
- Gene-by-exposure interactions in COPD onset: genome-wide methylation (epigenetics)
- Gene-lifestyle interaction replications (BP-smoking BP-alcohol lipids-smoking lipids-alcohol) for the CHARGE consortium
- Generation of HRV variables in LifeLines based on 10s ECGs for replication analysis of the VgHRV meta-GWAS consortium
- Genes and exposures underlying COPD onset in LifeLines
- Genetic and environmental determinants of blood pressure in the LifeLines Cohort Study: The role of obesity and the autonomic nervous system
- Genetic and environmental factors of age-related eye diseases
- Genetic and epigenetic determinants associated with skin autofluorescence and cardiovascular disease in diabetes
- Genetic background of cognitive control and depression: neurotransmitter and cellular function pathways
- Genetic origins of allergic diseases
- Genetic predisposition socioeconomic position and the risk of type 2 diabetes
- Genetics extension proposal: Candidate gene SNP analyses in Healthy Obesity Project
- Genetics of Water Balance Consortium: A GWAS of serum sodium
- Genome and metagenome risk prediction of complex traits in the prospective Lifelines cohort
- Genome of the Netherlands
- Genome-wide analysis for AGE-reader derived skin autofluorescence: discovery study
- Genome-wide analysis of Early Skeletal Growth using 1000 Genomes (March 2012 release) imputed data: EGG Consortium
- Genome-wide association scan of serum urea in a European population
- GIANT consortium 1000 Genomes analysis plan for height BMI and WHR adjusted for BMI (WHRadjBMI)
- Global Lipids Genetics/GIANT Consortium HRC and 1KG phase3 Imputation and Analysis plan
- GoNL Phenotypes
- Grandmaternal smoking – a modifiable transgenerational risk factor for childhood asthma?
- GWAS meta-analysis of average sleep duration and chronotype using the Munich Chronotype Questionnaire (MCTQ)
- GWAS meta-analysis of kidney function related traits and kidney disease by the CKDGen consortium (round 4)
- GWAS of several Calcium-related traits for inclusion in meta-GWAS for the CalciGen consortium
- GWAS on Well-being
- Harmonised air pollution and noise exposures linked to cardio-respiratory health in EU biobanks
- Health effects of chronic circadian disturbance due to shift work or evening blue light exposure
- Healthy Ageing at work: examining the relation between age health status and labour market participation in the LifeLines cohort
- Healthy aging in spondyloarthritis: using Lifelines to understand data from the Dutch part of the COMOrbidities in SpondyloArthritis (ComoSpA) study
- Healthy residential environments
- Heritability Genetics and Prognosis of Left Ventricular Electrical Active Mass
- Heritability Genetics and Prognosis of PR conduction
- Hernia Replication project
- ICBP GWAS 1000G Replication Analysis Plan of blood pressure related traits
- Identification of dementia risk profiles in children from people with dementia
- Identification of previously unknown (combinations of) phenotypes that are strongly heritable and identifying their genetic variants
- Identifying common genes for asthma and COPD
- Identifying Genetic Determinants of Between-Subject Variation in Neuroticism
- Identifying novel genes for lung function and lung function decline in LifeLines
- IgG immune response towards fecal bacteria of volunteers in comparison with IBD patients
- Impact of chronic diseases and chronic disease risk factors on work role functioning and labor market participation
- Incidence of cancer and risk factors
- Intake of cheese and other dairy products in relation to body weight and glucose in LifeLines
- Intake of protein and glycaemic index (GI) physical activity sleep stress and the associations with overweight and diabetes
- Jaarlijks (her)valideren van de door LifeLines bij de laboratoriumgeneeskunde geanalyseerde bepalingresultaten
- LifeLines “Deep”: Deep insight in the relationships between genetic variation methylation variation gene expression variation protein variation metabolite variation and phenotype variation
- LifeLines baseline pulmonary function and respiratory symptoms
- LifeLines Infinium HumanExome Chip Resource
- Lifestyle risk factors associated with the presence of cancer in the north of the Netherlands: A Cross-sectional study from the Lifelines cohort
- LL NEXT prenatal and early life data in LifeLines
- Magnesium Intake and Status in Relation to Health Problems and Complaints
- Managing life: individual differences in people’s capability to flexibly regulate their goals
- Markers of Imminent Myocardial Infarction (MIMI)
- Measurement of cortisol in scalp hair using LC-MS/MS: determination of a reference range and evaluation of hair sample collection in the LifeLines cohort study
- Menopause and cardiovascular risk factors
- Mental health and the onset of and adjustment to type 2 diabetes: A biopsychosocial approach
- Meta-Analysis on PCSK9 as a Target for the Prevention of Cardiovascular Events
- Metabolic pathways of increased cardiovascular risk in type 2 diabetes
- Methylation profiles in type 2 diabetes patients
- Microbes in Motion - Influence of the presence of chlorine and antibiotics in water on the gut microbiome
- Migrating from SF-36 to PROMIS: PROMIS Profile-29 reference scores and linking the SF-36 to PROMIS
- Mineralocorticoid receptor polymorphisms: association with stress-related psychiatric disorders and cardiac outcomes
- Modelling the phenotype in genetic associations: latent factor sum score and item level analyses
- Multifactorial disease trajectories
- NCD-RisC group
- Next Generation Sequencing in Extremes to Identify Functional Genetic Variants affecting Erythro- and Megakaryopoiesis
- Next Generation Sequencing in Extremes to Identify Functional Genetic Variants affecting Erythro- and Megakaryopoiesis
- Non-response of informal caregivers in the LifeLines cohort study
- Normal values for hormonal measurements
- Nutrient density as a measure of diet quality and associations with cardio-metabolic risk factors over the lifecourse
- Occupational exposure and the risk of congenital anomalies in the offspring
- Optimize the use of the RFFT as a cognitive measurement instrument in the LifeLines Cohort study
- PAGE (Physical activity functioning training and AGE (Advanced Glycation Endproducts))
- Parent-of-Origin Effects (POE) for BMI follow-up
- Pharmacogenetically relevant SNP’s and the use of medication in the LifeLines population
- Physical inactivity and chronic disease – is fatty liver the link?
- Polygenic Prediction Analysis for Personality and Wellbeing
- Prediction of pregnancy outcome: A LifeLines start of healthy ageing
- Prescription medication use and validation of baseline questionnaire data in the LifeLines cohort
- Presence of ACPA and CTD within the LifeLines cohort
- Prevalence and determinants of microalbuminuria in children
- Prevalence determinants and prognostic significance of ECG deviations in asymptomatic people
- Prevalence of depression in diagnosed and undiagnosed chronic somatic diseases
- Primary hypothyroidism in the LifeLines cohort study
- Profiles of Well-being and Affect: Changes from Young Adulthood via Middle Age to old Age
- Project Mantelzorg Informal caregiving: positive and negative aspects of caring for relatives with health problems
- Pulmonary function in patients with Parkinson’s disease
- Relation between total protein intake dairy- and non-dairy protein intake total dairy intake and intake of dairy product groups and estimates of muscle mass in the adult population
- Replication and discovery of single nucleotide polymorphisms associated with a wide range of quantitative biomedical traits in the LifeLines Cohort Study
- Replication of lung function SNPs for the UK10K consortium
- Replication of top SNPs for serum calcium for the CalciGen consortium
- REPROgen consortium analysis plan for 1000 Genomes Imputation GWAS for Reproductive Phenotypes - Age at menarche
- Risk for coronary artery disease and progression to heart failure
- ROHgen - a consortium to understand the influence of genome-wide homozygosity on complex traits
- ROHgen2 - GWAS meta analysis
- Social capital for healthy ageing; the social relational correlates of multimorbidity
- Social functioning as determinant of objective and subjective cognitive functioning in older persons (part I): a population-based cohort study
- Social Science Genetic Association Consortium 1000 Genomes analysis plan for Educational Attainment
- Socioeconomic health disparities within and between generations: The LifeLines Cohort Study
- Spatial scales of livability
- Stalking the wayward association between depression and neuropsychological functioning: can we get more clarity when considering lifespan stress comorbidity and familial vulnerability?
- Structural and functional aspects of social relations as determinants of physical and mental health outcomes in the LifeLines population
- Study on the epidemiology and genetics of Food allergy in the Netherlands
- Studying the molecular background of extreme lipid profiles through exome sequencing in the LifeLinesDeep cohort
- Succesful brain aging: How to compensate your bad habits?
- The aetiology of single and complex functional somatic syndromes
- The association between affective disorders and cognitive function in a population-based sample of young middle-aged and older adults
- The association between depression and neuropsychological functioning: can we get more clarity when considering lifespan stress comorbidity and familial vulnerability?
- The association between glucocorticoid receptor polymorphisms and components of the metabolic syndrome
- The association of obesity depression and their combination with health-related quality of life: Findings from the LifeLines study
- The benefit of having a partner: is it greater for Ill people than for healthy people?
- The co-evolution of well-being and the kinship network after parental divorce
- The consequence of family structures in LifeLines for the analysis of longitudinal non-normal data
- The Effect of Alcohol Consumption during Pregnancy on Offspring Overweight Obesity and Problem Behaviours over the Early Lifecourse
- The Effect of Gene and Early Life Social Environment Interaction on Daily and Organizational Behavior
- The Healthy Obese Project within the BioSHaRE-EU consortium; WP5
- The impact of the Groningen earthquakes on psycho-social well-being and health
- The influence of localized prescription glucocorticoids on long-term weight gain and associated cardiometabolic disturbances neurocognitive function and depression
- The influence of macronutrient dietary patterns on pregnancy weight gain birth outcomes and child health - a pooled cohort study
- The LifeLines cohort study: Protocol methodology and representativeness
- The mediating role of postive and negative affects in the relation between social support and health Social relationship factors SWB self-regulation health outcomes
- The Molecular Genetics of Dupuytren Disease
- The possible interrelationships between social relationship factors indicators of SWB self-regulation and health outcomes in a lifespan perspective
- The relation between dyslipidemia and type 2 diabetes is it causal? Insight from a genetic risk score approach
- The relation between inflammatory biomarkers and gastrointestinal and general health (DAG1)
- The roles of loneliness and social support in the association between health literacy and health behavior in older adults
- The succinate receptor: a master regulator of the renin-angiotensin system oxidative stress and tissue damage in chronic kidney disease
- The Sûn yn Fryslân project: Geographical mapping of lifestyle - and early risk factors of cardiovascular health in Fryslân
- The Triage instrument: (predictive) validity of the Groningen Frailty indicator the INTERMED client version and Wellbeing measure
- The validity and meaning of functional somatic syndrome diagnoses
- The Weather Chart
- To unravel the predictive value of C-reactive Protein and its genetic factors in the occurence of complex disease
- Towards longer worklife of people with chronic condition: influence of personality and compensation behaviour on labour market participation
- Trans-ethnic genome wide blood pressure meta-analysis
- Transethnic GWAS 1000G Analysis Plan of the MAGIC consortium (glucose related traits)
- Treatment of dyslipidemia for cardiovascular risk management according to Dutch and international guidelines – focus on extreme dyslipidemias
- UCP2 polymorphisms and their interaction with alcohol intake and obesity on liver function
- Uitgifte plasma samples voor biomarkers van DAG2 samples
- Uitgifte plasma samples voor Cytokines en CRP van DAG1 en DAG2
- Understanding different approaches of harmonization using individual participant data to investigate the determinants associated with age at menopause
- Validation of 24 hour creatinine prediction equation in the LifelInes population and its association with physical fitness
- Validation of imputation with GoNL and 1KG via GWAS meta-analysis on BMI lipids and Height
- Validation of the MINI Self Report questionnaire in LifeLines
- Validation of the SMAS-30/20 in different age groups and the development of a shorter version of the scale
- Vaststellen van referentiewaarden van laboratoriummetingen
- Vitamin B3 deficiency and tryptophan metabolism in low versus high socio-economic groups of the North-Netherlands LifeLines population
- Vitamin status in low versus high socio-economic groups of the North-Netherlands LifeLines population and the phenotypes of marginal/subclinical micronutrient deficiency
- Wealthier and healthier than my parents? Life course socioeconomic conditions and the intergenerational transmission of cardiovascular risk
- Whole-genome GxE analysis: Quantifying genetic difference between sexes and between populations for complex traits
- Whole-sequence based association analysis of cardiometabolic traits
- The role of activity in the predisposition and incidence of cardiovascular disease and diabetes as measured by clinical markers and self-report
- DAY! Early Detection of cAncer bY multi-cancer early detection assays (MCED)
- Long-Term Care Trajectories and Health Outcomes in Post-COVID Syndrome Patients: An Observational Study in the Netherlands
- Obesity-related physiological changes in children
- Modeling lifestyle-related health inequity; using data science to go from detailed individual data to general population- and GIS-based indicators (MOLHI)
- Metagenomics and host genetics as predictors of future diseases
- Examination of SGB-SGB interactions on intra-species SGB composition.
- HealThy fAt, haPpy mIcRobiome (TAPIR)
- Disentangling the association between sleep characteristics, psychosocial stress, and cognitive decline and dementia
- Bio-informatica minor 2024: Regional health patterns in the northern Netherlands
- The multi-omics signature of aging.
- Investigation of causal associations between feeling loved in childhood and depression and anxiety in adulthood using mediation and Mendelian randomization
- Sociodemographic, lifestyle, psychological and comorbid factors associated with atrial fibrillation and cardiovascular disease
- Vulnerability, Health Care Access and Public Policy
- Summer School Data Science and AI in Health
- EU EPHOR – working life exposome
- Primary prevention of cardiovascular disease simplified: which variables best predict relevant coronary calcification?
- Diabetes warning: effects on health and labour market outcomes
- Exploration of Genetic Variation, Drug Response, and Interactions Between Gastrointestinal Disorders and Other Diseases
- Dissect the Link Between Stress and Risk of Prediabetes and Type 2 Diabetes: Role of Modifiable Lifestyle and Psychological Factors
- The effects of parental adverse childhood experiences on parental allostatic load and the intergenerational transmission to offspring allostatic load
- ME/CFS Lines – Phase 2 biomaterials
- Ternary interaction among food nutrition, gut microbiota (bacteria, viruses, fungi), and human health
- The influence of lifestyle on head and neck cancer: factors beyond smoking and drinking
- Residential mobility and health (behavior) outcomes in adolescence and early adulthood
- Lifestyle and co-morbidities related to survival in patients diagnosed with cancer: a linkage between OncoLifeS, Lifelines and PALGA
- Dashboard brede welvaart: sociaaleconomische data en duiding
- Lifelines cohort Doelgroepen fietsveiligheid; Verandering van gezondheids- en sociodemografische kenmerken van groepen (wel/niet e-bike) fietsers over de afgelopen 10 jaar
- Identifying causal biological mechanisms in ME/CFS by a functional genetic approach
- The interaction effects of bilingual language experience and Alzheimer's Disease predisposition on cognitive performance and brain activity in middle-aged adults.
- Verschillen in gezondheid en zorggebruik
- Bachelor Thesis - Influence of ultra processed foods on the prevalence of coronary artery disease in the prospective Lifelines cohort
- Familial clustering of healthy lifestyle behaviors in Lifelines
- IBD-associated strain atlas
- Immune regulation of clonal hematopoiesis
- Unraveling the microbiota-immune axis and immune response dynamics in inflammatory bowel disease
- OP24_01009
- Causal inference and underlying mechanism between heart rate variability (cardiac autonomic function), mental health conditions and cardiovascular disease
- Age-specificity of risk and protective factors for affective disorders across the lifespan
- Mapping the Spatiotemporal Trajectories of Chronic Pain Across the Lifespan
- Exploring the relationship between online community engagement and mental health and well-being in diverse socially marginalized groups
- OV15-0276 antibiotics in Lifelines DAG3 Nose swabs
- Prevalence and socio-demographic characteristics of families with parents with a mental disorder in the neighborhoods of the Northern provinces of The Netherlands – a Lifelines cohort study
- Identifying environmental drivers of COVID-19 outcomes: an integrative exposome approach
- A systematical integrated analysis reveals the association between gut microbiota and mood disorder
- Participation in ARYC2024 - RUG/UMCG - Health Systems and Prevention track
- Participation in ARYC2024 - University of Groningen - Minor More Healthy Years
- Participation in ARYC2024 - Noorderpoort - Software Development
- Participation in ARYC2024 - Hanze University of Applied Sciences - Life Sciences & Technology
- Micro-econometric research using the unique "Lifelines data"
- Assessment of the neuroactive potential of the human gut microbiome across neuropathologies using the GBM2 computational pipeline
- Antagonistic pleiotropy of the ApoE genotype in memory
- Predicting Healthy or Unhealthy Aging through the Gut Microbiota Association Between Diet and Gut Microbiota
- Early Childhood Conditions and Later Outcomes
- Housing, care and welfare in Noordenveld: at home in the neighbourhood
- Early markers of chronic disease in people with autism and their caregivers-part 2
- Nonlinear biomarker discovery for survival analysis
- Unravelling the dark matter of infectious diseases, environmental and genetic factors tipping the balance towards NCDs. Proposal acronym: ID-DarkMatter-NCD
- ActiveLIFE
- Genome-wide association study (GWAS): Depression symptoms in adolescence across prospective and retrospective cohorts
- Exogenic sex steroid use and psychosis
- Omega-3 fatty acid consumption association to incident atrial fibrillation: a report of the Lifelines Cohort Study
- Identification of novel IBD-Related Microbial Gene Markers for Disease Stratification and Treatment
- Clonal competition in ageing haematopoiesis
- Next generation genomic resources for lifelines using linked-read sequencing
- Cancer Prevention and Epidemiology - NL: Examining the Trends and Impact of Modifiable Health Behaviors in Cancer (CPE-NL)
- Microbial Characteristics Associated with Different Clinical Phenotypes of Inflammatory Bowel Disease
- ArtDECO - The common variant landscape of congenital anomalies of the kidney and urinary tract
- Lifecourse Genome-wide association study (GWAS) analysis on selected phenotypes at different stages in the lifecourse
- Large scale multi-cohort metagenomic investigation of the human gut microbiome in health and disease.
- Investigating the Gut Microbiome’s Role in Health & Disease using Irritable Bowel Syndrome as a Disease Model
- Potentials and Challenges for the Introduction of Mobile Health Solutions in Rural Regions in Europe: Northern Netherlands vs Lusatia
- Biological aging and exposure to physical and psychological stress
- The Groningen Mental Health Initiative: Prevention of common mental disorders in the general population in the Netherlands
- Metagenomic polymorphic toxin effector and immunity profiling predicts microbiome development and disease-related dysbiosis
- Sex specific mediators of sleep disturbance effects on brain function
- Improving healthspan by personalized medicine with AI tools on omics, inflammation and other biomarkers of ageing
- Pathways between smoking and mental health
- Application of machine-learning on electrocardiograms (The future of electrocardiograms)
- Menopausal Fears
- LC-PUFAs and mental health outcomes: the role of overall diet quality, genetic susceptibility and fatty fish intake
- Preterm birth as a risk factor for noncommunicable diseases in the northern Netherlands: a retrospective cohort study
- Prevalentie van visuele beperkingen in Nederland (PREVISNED)
- The European Chronic Kidney Disease Burden Consortium
- Longitudinal modelling to uncover biological mechanisms underpinning metabolic and immunological diseases
- The characterization of Extracellular vesicles during aging and neurodegenerative diseases
- EXIMIOUS: Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome
- The general external exposome and risk of cardiometabolic diseases
- Imaging in Lifelines: MemoLife
- Cognitive benefits of regional language use (RELQ)
- The co-morbidities of smoking: uncovering underlying mechanisms
- Understanding changes in the human gut microbiome related to diet, lifestyle, and population history
- The prediction of COVID-19 and related symptoms in Lifelines
- Causal relationship between hemoglobin and hypertension: A Mendelian randomization study
- Thyroid GWAS Analysis Plan for increased/decreased TSH, TSH, FT4 and T3, T3/T4 ratio, and TSH*FT4 product - extended project
- Exploring longitudinal associations between the food and physical activity environment and weight
- Mapping of changes in frailty in elderly during a pandemic
- DNNs for Disease Classifaction on Phylogenetic Trees (LL DEEP - EGA)
- Determination of correlations between polygenic risk scores of 40 traits and actual outcomes
- Genetic risk score analysis of kidney function decline in the CKDGen Progression Project
- GWAS of serum vitamin B12 and methylmalonic acid (MMA)
- Fibroblast growth factor 23 in relation to phosphate and classical cardiovascular risk factors in patients with diabetes mellitus type 1 compared to controls
- Peripartum depression and anxiety disorders
- Municipal Purchasing Strategies in Youth Mental Healthcare: Evaluating Cost-Effectiveness and Outcomes of Care Trajectories for Children with Complex Mental Problems (MUNI-CARE)
- Unraveling the Mind-Heart Connection: Exploring Depressive symptoms and Cardiovascular Traits in the Lifelines Cohort Study
- Does the duration of the reproductive phase (years from menarche to menopause) have an impact on the cognitive status in old age?
- ExquAIro AI bootcamp
- Participation in ARYC2023 - University of Groningen - Minor More Healthy Years
- Participation in ARYC2023 - RUG/UMCG - Health Systems and Prevention track
- Participation in ARYC2023 - Hanze University of Applied Sciences - Minor Healthy Ageing
- Participation in ARYC2023 - Noorderpoort - Software Development
- Participation in ARYC2023 - Hanze University of Applied Sciences - Life Sciences & Technology
- Genomic and functional diversity of Lachnospiraceae, Bifidobacterium, Christensenellaceae and Faecalibacterium in human microbiota.
- Sodium intake and mortality Part 2
- Tinnitus, hearing loss, cognition and infection in adults and children
- Muscle mass and health: relation with nutrition, physical activity and comorbidities in different weight classes
- Investigating the impact of the coronavirus pandemic on internalizing and functional symptoms and disorders in the Lifelines Biobank
- Biological Age Study in Lifelines
- Mental health and the progression from normal glucose levels, to prediabetes, and to type 2 diabetes
- Consumption of total dairy and dairy subtypes with incident prediabetes in the Lifelines study population
- Genetics of irritable bowel syndrome and gastrointestinal complaints
- Estimating Dutch reference scores for the PROMIS-29 Profile
- Genomewide association study of osteoarthritis and joint pain
- Age specific prevalence of sleep problems and anxiety disorder: Data from the Lifelines cohort
- Large-scale genome-wide association meta-analyses of physical activity
- Genome-wide association study on income
- Heritability and genetic risk factors for tinnitus
- Life-Course Transitions, Socioeconomic Status and Health Behaviours
- Lifestyle as a multi-organ target to improve health outcomes
- Polygenic interactions with environmental factors in the etiologies of depression, anxiety disorder, obesity and substance use
- Metabolic Health in older Adulthood The Retirement Transition
- Lifelines Corona Research Project (COVQ)
- Exploring the relationship between mental health and gut microbiome in Western and non-Western settings
- Association between inflammatory potential of diet and vascular calcification in individuals with early-stage CKD
- Local norms, political discontent and health behaviors: investigating novel determinants of geographic and intergenerational differences in health behaviors
- A multi-omic machine-learning framework for disease classification
- Anxiety during Lockdown
- Project Centre of Public Health in Economics and Business
- Advancing occupational health research: unlocking prospective cohorts to bridge knowledge gaps in occupational exposure and the burden of disease
- Reference interval determination for multiple blood and urine parameters
- Vestibular Loss: Investigating Its Prevalence, Risk Factors, Genetic Contributors, and Impact on Quality of Life
- Publications
- A spatial analysis of dietary patterns in a large representative population in the north of The Netherlands - the Lifelines cohort study
- Influence of Storage and Inter- and Intra-Assay Variability on the Measurement of Inflammatory Biomarkers in Population-Based Biobanking.
- Lipid and lipoprotein reference values from 133,450 Dutch Lifelines participants: Age- and gender-specific baseline lipid values and percentiles
- The Well-Known Gene HHIP and Novel Gene MECR Are Implicated in Small Airway Obstruction
- Anxiety among healthcare workers during the COVID-19 pandemic: a longitudinal study
- Host genetic regulation of human gut microbial structural variation
- Types of fish consumption differ across socioeconomic strata and impact differently on plasma fish-based omega-3 fatty acids: A cross-sectional study
- Work- and mental health-related events and body mass index trajectories during the Covid-19 lockdown. Evidence from the lifelines cohort study in the Netherlands
- The relation between depression, anxiety and psychotropic drugs on the gut microbiome
- Factors associated with SARS-COV-2 positive test in Lifelines
- Do differences in sport participation contribute to socioeconomic health inequalities? Evidence from the Lifelines cohort study on all-cause mortality, diabetes and obesity
- Prevalence, risk factors and optimal way to determine overweight, obesity and morbid obesity, in the first Dutch cohort of very long-term survivors of childhood cancer: a DCCSS-LATER study
- Impact of health-related behavioral factors on participation in a cervical cancer screening program: the lifelines population-based cohort
- Nonlinear associations between insomnia symptoms and circadian preferences in the general population: symptom-specific and lifespan differences in men and women
- Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram
- Long-term cortisol exposure and associations with height and comorbidities in Turner syndrome
- Course of frailty stratified by physical and mental multimorbidity patterns: a 5-year follow-up of 92,640 participants of the LifeLines cohort study
- Neighborhood income and major depressive disorder in a large Dutch population: results from the LifeLines Cohort study.
- Effective questionnaire-based prediction models for type 2 diabetes across several ethnicities: a model development and validation study
- Mental disorders and loneliness among adults with atopic dermatitis in the Dutch general population
- Reproducibility of a combined artificial intelligence and optimal-surface graph-cut method to automate bronchial parameter extraction
- Differences in lipid and blood pressure measurements between individuals with type 1 diabetes and the general population
- Anxiety disorders and CRP in a population cohort study with 54326 participants: The LifeLines study.
- Dairy consumption and incident prediabetes: prospective associations and network models in the large population-based Lifelines study
- Serious mental illness and cardiovascular health: Observational and polygenic risk score analyses in a population-based cohort study
- Depression, Anxiety, and the Risk of Cancer Incidence
- Lifelines Family Ties "Multi-functional ties and well-being in family networks before and after parental divorce"
- Deep learning for automated exclusion of cardiac CT examinations negative for coronary artery calcium
- The physical and mental burden of dry eye disease: A large population-based study investigating the relationship with health-related quality of life and its determinants
- Wnt signaling and Dupuytren's disease.
- Socio-economic disparities in the association of diet quality and Type 2 Diabetes incidence in the Dutch Lifelines Cohort
- Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
- Volatile organic compounds in breath as markers for irritable bowel syndrome: a metabolomic approach.
- Comparison of cognitive functioning as measured by the Ruff Figural Fluency Test and the CogState computerized battery within the LifeLines Cohort Study
- Diet quality, stress and common mental health problems: A cohort study of 121,008 adults
- Reference values of heart rate variability from 10-second resting electrocardiograms: the Lifelines Cohort Study
- A positive neighborhood walkability is associated with a higher magnitude of leisure walking in adults upon COVID-19 restrictions: a longitudinal cohort study
- A comparative analysis of the incidence, severity and duration of smell and taste loss in COVID-19 cases versus non-COVID-19 cases: a longitudinal cohort study.
- Casting wider nets for anxiety and depression: disability-driven cross-diagnostic subtypes in a large cohort.
- A physically active lifestyle is related with a lower level of skin autofluorescence in a large chronic disease population (LifeLines cohort)
- Psychological, behavioural, and physical aspects of caregiver strain in autism-caregivers: a cohort study
- Association of recognized and unrecognized myocardial infarction with depressive and anxiety disorders in 125,988 individuals: a report of the LifeLines Cohort Study
- Comorbid Depressive and Anxiety Symptoms and the Risk of Type 2 Diabetes: Findings from the Lifelines Cohort Study.
- Unraveling the associations of age and menopause with cardiovascular risk factors in a large population-based study
- Educational inequalities in metabolic syndrome prevalence, timing, and duration amongst adults over the life course: a microsimulation analysis based on the Lifelines Cohort Study
- Hypothyroidism, comorbidity and health-related quality of life: a population-based study
- PSYCHIATRIC COMORBIDITY DOES NOT ONLY DEPEND ON DIAGNOSTIC THRESHOLDS: AN ILLUSTRATION WITH MAJOR DEPRESSIVE DISORDER AND GENERALIZED ANXIETY DISORDER.
- Potential Biomarkers for Fat from Dairy and Fish and Their Association with Cardiovascular Risk Factors: Cross-sectional Data from the LifeLines Biobank and Cohort Study.
- Single-cell dissection of the immune response after acute myocardial infarction
- Association of personality facets and cognition in the Lifelines population-based Study
- Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study
- HS tarda: defining an understudied population of hidradenitis suppurativa among elderly
- The relationship between depression and executive function and the impact of vascular disease burden in younger and older adults
- Greater Adherence to a Mediterranean Diet is Associated with lower C-reactive Protein (CRP) levels, but not to lower odds of having Dry Eye Disease
- Metabolic syndrome increases the risk for premature employment exit: A longitudinal study among 60,427 middle-aged and older workers from the Lifelines Cohort Study and Biobank
- The relationship between social functioning and subjective memory complaints in older persons: a population-based longitudinal cohort study.
- Trajectories of Self-Rated Health in an Older General Population and Their Determinants: The Lifelines Cohort Study
- Cheese and Healthy Diet: Associations With Incident Cardio-Metabolic Diseases and All-Cause Mortality in the General Population
- Proactive screening for symptoms: A simple method to improve early detection of unrecognized cardiovascular disease in primary care. Results from the Lifelines Cohort Study
- Symptom profiles and their risk factors in patients with post COVID-19 condition: A longitudinal Dutch observational cohort study
- Anxiety disorders and figural fluency: a measure of executive function
- Familial Co-aggregation and Shared Genetics of Cardiometabolic Disorders and Traits: Data from The Multi-Generational Lifelines Cohort Study
- Psychiatric disorders and the onset of self-reported fibromyalgia and chronic fatigue syndrome: The Lifelines cohort study
- Lifestyle factors related to prevalent chronic disease multimorbidity: A population-based cross-sectional study
- Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
- Associations of Diet Quality and All-Cause Mortality across Levels of Cardiometabolic Health and Disease: A 7.6-Year Prospective Analysis from the Dutch Lifelines Cohort
- Prevalence of electrocardiographic unrecognized myocardial infarction and its association with mortality
- Geriatric Syndromes and Incident Chronic Health Conditions Among 9094 Older Community-Dwellers: Findings From the Lifelines Cohort Study
- Seventy-five genetic loci influencing the human red blood cell.
- Dose–response association between moderate to vigorous physical activity and incident morbidity and mortality for individuals with a different cardiovascular health status: A cohort study amo
- Unfavourable blood pressure and LDL-cholesterol levels in obese non-diabetic individuals
- Early imaging biomarkers of lung cancer, COPD and coronary artery disease in the general population: rationale and design of the ImaLife (Imaging in Lifelines) Study
- Understanding Trends in Loneliness During the COVID-19 Pandemic in the Netherlands: The Moderating Role of Gender, Age, and Living Arrangement
- The Lifelines Cohort Study: Prevalence and treatment of cardiovascular disease and risk factors.
- Data-driven assessment, contextualisation and implementation of 134 variables in the risk for type 2 diabetes: an analysis of Lifelines, a prospective cohort study in the Netherlands
- Susceptibility to chronic mucus hypersecretion, a genome wide association study.
- The Combined Effects of Obesity, Abdominal Obesity and Major Depression/Anxiety on Health-Related Quality of Life: the LifeLines Cohort Study.
- Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome
- CT-based emphysema characterization per lobe: A proof of concept
- Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults
- Skin autofluorescence predicts new cardiovascular disease and mortality in people with type 2 diabetes
- Representativeness of the LifeLines Cohort Study
- Long-term exposure to road traffic noise, ambient air pollution, and cardiovascular risk factors in the HUNT and Lifelines cohorts
- Survey nonresponse among informal caregivers: effects on the presence and magnitude of associations with caregiver burden and satisfaction.
- Validation of an AI-based algorithm for measurement of the thoracic aortic diameter in low-dose chest CT
- A Dual UHPLC-HRMS-Based Fecal Metabolomics and Lipidomics Analysis and Automated Data Processing Pipeline for Comprehen-sive Gut Phenotyping
- The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies.
- KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern
- Development and validation of a questionnaire-based myopia proxy in adults: the LifeLines Cohort Study
- The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.
- Economic Conditions at Birth and Cardiovascular Disease Risk in Adulthood: Evidence from New Cohorts
- Skin autofluorescence predicts new cardiovascular disease and mortality in people with type 2 diabetes
- Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals
- Erythrocytosis in the general population: clinical characteristics and association with clonal hematopoiesis
- Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk: A Cross-Sectional Study
- SNP-Based Heritability Estimates of Common and Specific Variance in Self- and Informant-Reported Neuroticism Scales.
- The association of air pollution and depressed mood in 70,928 individuals from four European cohorts.
- Non-LDL dyslipidemia is prevalent in the young and determined by lifestyle factors and age: The LifeLines cohort.
- Impact of Occupational Pesticide Exposure on the Human Gut Microbiome
- Risk factors for chronic mucus hypersecretion in individuals with and without COPD: influence of smoking and job exposure on CMH.
- Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
- Relative fat mass and prediction of incident atrial fibrillation, heart failure and coronary artery disease in the general population
- Mitochondrial Genome Study Identifies Association Between Primary Open-Angle Glaucoma and Variants in MT-CYB, MT-ND4 Genes and Haplogroups
- SORTA: a system for ontology-based re-coding and technical annotation of biomedical phenotype data.
- Dietary patterns and physical activity in the metabolically (un)healthy obese: the Dutch Lifelines cohort study
- How to ensure inclusivity in large-scale general population cohort studies? Lessons learned with regards to including and assessing sex, gender and sexual orientation.
- Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged ≥80 years
- The interaction of socioeconomic position and type 2 diabetes mellitus family history: a cross-sectional analysis of the Lifelines Cohort and Biobank Study
- Multimorbidity prevalence and patterns and their associations with health literacy among chronic kidney disease patients
- Lipid and lipoprotein reference values from 133,450 Dutch Lifelines participants: Age- and gender-specific baseline lipid values and percentiles
- Polygenic risk associations with clinical characteristics and recurrence of Dupuytren’s disease
- Observational and two-sample Mendelian randomization support a bidirectional relation between red blood cell traits and diastolic blood pressure
- Changes in anxiety and depression symptoms during the Covid-19 lockdown in the Netherlands. The moderating role of pre-existing mental health, employment situation and alcohol consumption
- Development and internal validation of a prediction model for the presence of tinnitus in a Dutch population-based cohort
- Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: A large Dutch population cohort
- Symptom burden and quality of life before, during and after a SARS-CoV-2 PCR positive or negative test: results from LIFELINES
- The association between various smoking behaviors, cotinine biomarkers and skin autofluorescence, a marker for advanced glycation end product accumulation
- Do Uncontrolled Hypertension, Diabetes, Dyslipidemia, and Obesity Mediate the Relationship Between Health Literacy and Chronic Kidney Disease Complications?
- Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
- Cardiovascular Risk Factors and Coronary Calcification in a Middle-aged Dutch Population: The ImaLife Study.
- Time to improve statin prescription guidelines in low-risk patients?
- A retrospective cross-sectional study on tinnitus prevalence and disease associations in the Dutch population-based cohort Lifelines
- Psychiatric disorders comorbid with general medical and functional somatic disorders: The Lifelines cohort study
- The effect of feedback on cardiovascular risk factors on optimization of primary prevention: the Pharmlines Initiative
- Road traffic noise, blood pressure and heart rate: Pooled analyses of harmonized data from 88,336 participants.
- Chronic hydrochlorothiazide use and the risk of skin cancer in Caucasian adults with hypertension – A PharmLines initiative inception cohort study
- Association between dementia parental family history and mid-life modifiable risk factors for dementia: a cross-sectional study using propensity score matching within the Lifelines cohort
- A comparison of cardiovascular and pulmonary morbidities in breast cancer survivors compared to an age-matched female control group in the LifeLines prospective population cohort
- Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits
- High prevalence of apolipoprotein B dyslipoproteinemias in non-alcoholic fatty liver disease: The lifelines cohort study
- Prescription of statins in suspected non-alcoholic fatty liver disease and high cardiovascular risk, a population-based study
- From evidence to practice: development of web-based Dutch lipid reference values
- The Genome of the Netherlands: design, and project goals.
- Associations of Positive Affect and Negative Affect with Allostatic Load: a Lifelines Cohort Study
- Blood Eosinophil Count and Metabolic, Cardiac and Pulmonary Outcomes: A Mendelian Randomization Study
- The role of life-course socioeconomic and lifestyle factors in the intergenerational transmission of the metabolic syndrome: results from the LifeLines Cohort Study.
- Thyroid hormone status and health-related quality of life in the LifeLines Cohort Study.
- Work functioning of Dutch workers with a chronic disease in early, mid and late working life: cross-sectional findings from 38,470 participants in the Lifelines Cohort Study
- Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
- Skin autofluorescence predicts incident type 2 diabetes, cardiovascular disease and mortality in the general population
- Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire
- Determinants of HbA1c in nondiabetic Dutch adults: genetic loci and clinical and lifestyle parameters, and their interactions in the Lifelines Cohort Study.
- Fast-food environments and BMI changes in the Dutch adult general population: the Lifelines cohort
- Socioeconomic Inequalities in pediatric Metabolic Syndrome: mediation by parental health literacy
- Development and validation of a prediction model for unemployment and work disability among 55 950 Dutch workers
- Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
- Higher skin autofluorescence in individuals at risk for rheumatoid arthritis: results from a large population based cohort.
- Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
- Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study
- Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
- New genetic loci link adipose and insulin biology to body fat distribution.
- Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure.
- New gene functions in megakaryopoiesis and platelet formation
- Sugar-sweetened beverages, low/no-calorie beverages, fruit juice and non-alcoholic fatty liver disease defined by fatty liver index: the SWEET project
- Cohort profile: women of reproductive age living in the North of the Netherlands: Lifelines Reproductive Origins of Adult Health and Disease cohort (Lifelines-ROAHD)
- Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study
- Self-reported systemic sclerosis-related symptoms are more prevalent in subjects with Raynaud’s phenomenon in the general population
- Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals
- Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
- Effects of Education and Income on Incident Type 2 Diabetes and Cardiovascular Diseases: a Dutch Prospective Study
- Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.
- Stress-related exposures amplify the effects of genetic susceptibility on depression and anxiety
- Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
- Diet quality, food intake and incident adult-onset asthma: a LifeLines Cohort Study
- Do Poor Diet and Lifestyle Behaviors Modify the Genetic Susceptibility to Impulsivity in the General Population?
- A non-invasive risk score including skin autofluorescence predicts diabetes risk in the general population
- Sex and gender differences in primary care help-seeking for common somatic symptoms: a longitudinal study
- Population-level analysis of gut microbiome variation.
- Multimorbidity and exit from paid employment: the effect of specific combinations of chronic health conditions
- Obesity Is Common in Axial Spondyloarthritis and Is Associated with Poor Clinical Outcome.
- No convincing association between genetic markers and respiratory symptoms: results of a GWA study
- The genomic landscape of reference genomes of cultivated human gut bacteria
- Mood and Anxiety Disorders in Chronic Fatigue Syndrome, Fibromyalgia, and Irritable Bowel Syndrome: Results From the LifeLines Cohort Study.
- Discovery and refinement of loci associated with lipid levels.
- Higher free triiodothyronine is associated with non-alcoholic fatty liver disease in euthyroid subjects: the Lifelines cohort Study
- Associations between smoking, components of metabolic syndrome and lipoprotein particle size.
- Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands
- Association of asthma genetic variants with asthma-associated traits reveals molecular pathways of eosinophilic asthma
- Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.
- The effect of extended participation windows on attendance at cervical cancer screening
- Plasma phosphate and all-cause mortality in individuals with and without type 2 diabetes: the Dutch population-based lifelines cohort study
- Understanding the genetic complexity of puberty timing across the allele frequency spectrum
- Lifestyle and clinical determinants of skin autofluorescence in a population-based cohort study.
- GlycA, a biomarker of low-grade inflammation, is increased in male night shift workers
- Loci influencing blood pressure identified using a cardiovascular gene-centric array.
- Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome
- Adherence to guidelines to prevent cardiovascular diseases: The LifeLines cohort study
- Observational and genetic evidence support a relationship between cardiac autonomic function and blood pressure
- Hair analysis reveals subtle HPA axis suppression associated with use of local corticosteroids: The Lifelines cohort study.
- Noise and somatic symptoms: A role for personality traits?
- Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
- Predicted versus CT-derived total lung volume in a general population: The ImaLife study
- Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
- Pleiotropic genes for metabolic syndrome and inflammation.
- The decreasing prevalence of ADHD across the adult lifespan confirmed
- Sex disparities in the effect of statins on lipid parameters: The PharmLines Initiative
- Sugar and low/no-calorie-sweetened beverage consumption and associations with body weight and waist circumference changes in five European cohort studies: the SWEET project
- Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
- Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
- Associations of relative fat mass, a new index of adiposity, with type-2 diabetes in the general population
- Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose
- Metabolic features and glucocorticoid-induced comorbidities in patients with giant cell arteritis and polymyalgia rheumatica in a Dutch and Danish cohort
- The work-related burden of dry eye
- High prevalence of metabolic syndrome features in patients previously treated for nonfunctioning pituitary macroadenoma.
- The Relationship Between Sedentary Behavior and Dry Eye Disease
- Antimicrobial resistance genes aph(3’)-III, ermB, sul2 and tetW abundance in animal faeces, products, production environments and human faeces in Europe
- Glucocorticoid Receptor Haplotype and Metabolic Syndrome: the Lifelines Cohort Study.
- Workplace impact on employees: a Lifelines Corona Research Initiative upon return to work
- Limited health literacy and its associated health outcomes among adults with at least two atopic diseases
- The longitudinal association between working from home and musculoskeletal pain during the COVID-19 pandemic
- Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
- Genome-wide association study identifies variants associated with autoimmune hepatitis type 1.
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
- Psychological, behavioural and biological factors associated with gastrointestinal symptoms in autistic adults and adults with autistic traits
- Health-Related Quality of Life in Relation to Obesity Grade, Type 2 Diabetes, Metabolic Syndrome and Inflammation
- Genome-wide association study identifies 74 loci associated with educational attainment.
- Identification of Lifelines participants at high risk for development of rheumatoid arthritis
- Clonal hematopoiesis and abnormal platelet counts in the general population
- Real-World Effects of Antibiotic Treatment on Acute COPD Exacerbations in Outpatients: A Cohort Study under the PharmLines Initiative
- GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence.
- Low Sodium Intake, Low Protein Intake, and Excess Mortality in an Older Dutch General Population Cohort: Findings in the Prospective Lifelines-MINUTHE Study
- Microbial vitamin production mediates dietary effects on diabetic risk
- Is Rigorous Retrospective Harmonization Possible? Application of the DataSHaPER Approach across 53 Large Studies
- Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
- Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus
- Prediabetes and the risk of type 2 diabetes: investigating the roles of depressive and anxiety symptoms in the Lifelines Cohort Study
- Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations
- The necessity of incorporating non-genetic risk factors into polygenic risk score models
- Phenotypic and genetic factors are associated with absence of cardiomyopathy symptoms in PLN c.40_42delAGA carriers
- Neighborhood socioeconomic differences in BMI: The role of fast-food outlets and physical activity facilities
- Human Fertility, Molecular Genetics, and Natural Selection in Modern Societies
- Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels
- Health Literacy Is Associated With Health Behaviors and Social Factors Among Older Adults: Results from the LifeLines Cohort Study.
- Genome-wide genetic homogeneity between sexes and populations for human height and body mass index.
- GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
- Musical and multilingual experience to promote healthy aging: better some than none but even better together
- Evidence for Genetic Overlap between Schizophrenia and Age at First Birth in Women
- Age-dependent sex differences in cardiometabolic risk factors
- Dutch government invests in existing biobanks
- Socioeconomic differences in metabolic syndrome development and the mediating role of perceived stress from long-term difficulties: a longitudinal analysis of the Lifelines Cohort Study
- Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for long function and pulmonary fibrosis
- The association of low muscle mass with prevalence and incidence of type 2 diabetes in different BMI classes
- Noninvasive detection of any-stage cancer using free glycosaminoglycans
- Socio-economic gradients in diagnosed and undiagnosed Type 2 diabetes and its related health complications
- FTO genotype is associated with phenotypic variability of body mass index.
- Do influence at work and possibilities for development mitigate the impact of job demands for workers with and without depression
- Does natural selection favour taller stature among the tallest people on earth?
- Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
- Circulating adipokine levels associate with COVID-19 severity in hospitalized patients
- Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
- Effects of previous growth hormone excess and current medical treatment for acromegaly on cognition.
- Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
- A saturated map of common genetic variants associated with human height (from 5.4 million individuals of diverse ancestries)
- Exploring how biobanks communicate the possibility of commercial access and its associated benefits and risks in participant documents
- Reward sensitivity across the lifespan in males and females and its associations with psychopathology problems
- The mediating role of physical activity and sedentary behavior in the association between working from home and musculoskeletal pain during the COVID-19 pandemic
- Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
- Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
- Genetic studies of body mass index yield new insights for obesity biology.
- Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits.
- Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index
- Association of sweetened beverages consumptions with all-cause mortality risk among Dutch adults: the Lifelines Cohort Study
- Exploration of genome-wide DNA methylation profiles in night shift workers
- Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
- Shrunken pore syndrome in childhood cancer survivors treated with potentially nephrotoxic therapy
- Do social relations buffer the effect of neighborhood deprivation on helath-related quality of life? Results from the Lifelines Cohort Study
- Functional limitations in functional somatic syndromes and well-defined medical diseases. Results from the general population cohort LifeLines.
- A capital-based approach to better understand health inequalities: Theoretical and empirical explorations
- Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
- Disentangling the association between alcohol consumption and employment status: causation, selection or confounding?
- Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention”
- Cognition and brain abnormalities on MRI in pituitary patients.
- Defining the role of common variation in the genomic and biological architecture of adult human height.
- Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits.
- Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics
- Socioeconomic differences in major depressive disorder onset among adults are partially explained by lifestyle factors: a longitudinal analysis of the Lifelines Cohort Study
- Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study
- The association between the presence of fast-food outlets and BMI: the role of neighbourhood socio-economic status, healthy food outlets, and dietary factors
- Cohort Profile: LifeLines, a three-generation cohort study and biobank
- Cognitive performance after postoperative pituitary radiotherapy: a dosimetric study of the hippocampus and the prefrontal cortex.
- Genetic, parental and lifestyle factors influence telomere length
- Chronic multimorbidity impairs role functioning in middle-aged and older individuals mostly when non-partnered of living alone
- Increases in symptoms of depression and anxiety in adults during the initial phases of the COVID-19 pandemic are limited to those with less resources: Results from the Lifelines Cohort Study
- Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
- DataSHIELD: taking the analysis to the data, not the data to the analysis
- Environmental factors shaping the gut microbiome in a Dutch population
- Consent procedures in pediatric biobanks
- Diagnostic Value of Urinary Steroid Profiling in the Evaluation of Adrenal Tumors.
- Cognitive functioning in patients treated for nonfunctioning pituitary macroadenoma and the effects of pituitary radiotherapy.
- The validity of self-reported cancer in a population-based cohort compared to that in formally registered sources
- Construct validity of the Groningen Frailty Indicator established in a large sample of home-dwelling elderly persons: Evidence of stability across age and gender.
- Combined Effects of Smoking and Alcohol on Metabolic Syndrome: The LifeLines Cohort Study
- Blood lipids influence DNA methylation in circulating cells.
- Cognitive task performance and subjective cognitive symptoms in individuals with Chronic Fatigue Syndrome or Fibromyalgia: A cross-sectional analysis of the Lifelines cohort study
- Frailty and risk of hospitalization from COVID-19 infection among older adults: evidence from the Dutch Lifelines COVID-19 Cohort study
- Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile
- The association between the presence of fast-food outlets and BMI: the role of neighbourhood socio-economic status, healthy food outlets, and dietary factors
- Comparing the hub-and-spoke model practices of the LifeLines Study in the Netherlands and the H3Africa Initiative
- Lifestyle patterns and incident type 2 diabetes in the Dutch lifelines cohort study
- Frailty and affective disorders throughout adult life: a 5-year follow-up of the Lifelines Cohort Study
- The Relationship Between Habitual Water Intake and Dry Eye Disease
- Common variants associated with plasma triglycerides and risk for coronary artery disease.
- Association of Depressive and Anxiety Disorders With Diagnosed Versus Undiagnosed Diabetes: An Epidemiological Study of 90,686 Participants.
- The risk factors for self-reported fibromyalgia with and without multiple somatic symptoms: The Lifelines cohort study
- Circulating de novo lipogenesis fatty acids and all-cause mortality in a prospective Dutch population cohort
- Dose-Response and Substitution Analyzes of Sweet Beverage Consumption and Body Weight in Dutch Adults: The Lifelines Cohort Study
- A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides
- Active recruitment and limited participant-load related to high participation in large population-based biobank studies.
- Validation and comparison of 28 risk prediction models for coronary artery disease
- Adult onset asthma and interaction between genes and active tobacco smoking: The Gabriel-consortium
- The Dutch Childhood Cancer Survivor Study (DCCSS)-LATER 2 kidney analysis examined long-term glomerular dysfunction in childhood cancer survivors
- Longitudinal GWAS meta-analyses in >330,000 individuals identify new genetic loci for annual kidney function decline and large subgroup effects
- Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
- Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation
- PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.
- Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
- Socioeconomic differences in metabolic syndrome development among males and females, and the mediating role of health literacy and self-management skills
- A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
- A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol
- Long-Term Tubular Dysfunction in Childhood Cancer Survivors; DCCSS-LATER 2 Renal Study
- Measurement properties of the Dutch PROMIS-29 v2.1 profile in people with and without chronic conditions
- Absolute and Relative Socioeconomic Health Inequalities across Age Groups
- Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution.
- Hypertension in long-term childhood cancer survivors after treatment with potentially nephrotoxic therapy; DCCSS-LATER 2: Renal study
- Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach.
- Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
- A novel biomarker panel for irritable bowel syndrome and the application in the general population.
- Increased genetic contribution to wellbeing during the COVID-19 pandemic
- Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study
- The risk factors for self-reported Irritable Bowel Syndrome with prior psychiatric disorder: The Lifelines cohort study
- Monocytosis and its association with clonal hematopoiesis in community-dwelling individuals: data from a prospective population-based cohort study
- A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function
- Transitioning out of work and metabolic syndrome incidence: a longitudinal study among 13 303 older workers from the Lifelines Cohort Study and Biobank
- Associations of 24 h urinary excretions of α- and γ-carboxyethyl hydroxychroman with plasma α- and γ-tocopherol and dietary vitamin E intake in older adults: the Lifelines-MINUTHE Study
- Air pollution exposure is associated with restrictive ventilatory patterns
- Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms.
- The predictors of multiple somatic symptoms in a population sample: The Lifelines cohort study
- (Un)Healthy in the city: Respiratory, Cardiometabolic and Mental Health Associated with Urbanity
- Loneliness associates strongly with anxiety and depression during the COVID pandemic, especially in men and younger adults
- Do chronic diseases moderate the association between psychosocial working conditions and work ability and involuntary work exit? Results from 55,950 Dutch workers
- Validation of a clinical and genetic model for predicting severe COVID-19
- Pesticides and other occupational exposures are associated with airway obstruction: the LifeLines cohort study.
- CT characteristics of solid pulmonary nodules of never smokers versus smokers: A population-based study
- Ultra-processed food consumption and kidney function decline in a population-based cohort in the Netherlands
- Proton pump inhibitors affect the gut microbiome.
- Frailty among older people during the first wave of the Covid-19 pandemic in the Netherlands
- Familial co-aggregation and shared heritability between depression, anxiety, obesity and substance use
- Reference Intervals for Sysmex XN Hematological Parameters as assessed in the Dutch Lifelines Cohort
- GST-omega genes interact with environmental tobacco smoke on adult level of lung function.
- Using Structural Equation Modeling to Untangle Pathways of 5 Risk Factors Associated with Incident Type 2 Diabetes: The 6 Lifelines Cohort Study
- Airflow limitation increases lung cancer risk in smokers: the Lifelines cohort study
- Working from home during the COVID-19 pandemic and its longitudinal association with physical activity and sedentary behavior
- Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study.
- Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.
- Moderate-to-severe atopic dermatitis and lifestyle factors in the Dutch general population
- Agreement between Computerized and Human Assessment of Performance on the Ruff Figural Fluency Test.
- Night-shift work is associated with increased susceptibility to COVID-19 infection
- Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics.
- Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.
- Exposure and work-related factors in subjects with hand eczema: data from the Lifelines Cohort study
- The association between unemployment trajectories and alcohol consumption patterns. Evidence from a large prospective cohort in The Netherlands
- WNT2 locus is involved in genetic susceptibility of Peyronie's disease.
- Analysis of Normal Levels of Free Glycosaminoglycans in Urine and Plasma in Adults
- Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
- Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects form the International Cannabis Consortium
- Occupational exposure to vapors, gases, dusts, and fumes is associated with small airways obstruction.
- Whole-genome sequence variation, population structure and demographic history of the Dutch population
- Eosinophil Count Is a Common Factor for Complex Metabolic and Pulmonary Traits and Diseases: The LifeLines Cohort Study.
- Impact of the COVID-19 pandemic on adults with moderate-to-severe atopic dermatitis in the Dutch general population
- Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis.
- The structure of the symptoms of major depression: Factor analysis of a lifetime worst episode of depressive symptoms in a large general population sample
- Night shift work characteristics are associated with several elevated metabolic risk factors and immune cell counts in a cross-sectional study
- Genetic Determinants of P Wave Duration and PR Segment
- Pleiotropic Effects of Lipid Genes on Plasma Glucose, HbA1c, and HOMA-IR Levels
- Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
- NOS1: A Susceptibility Gene for Reduced Level of FEV1 in the Setting of Pesticide Exposure.
- Validation of a clinical and genetic model for predicting severe COVID-19
- Prevalence of systemic lupus erythematosus-related symptoms assessed by using the Connective Tissue Disease Screening Questionnaire in a large population-based cohort
- Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
- Cohort Profile Update: Lifelines, a three-generation cohort study and biobank
- Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C
- Western and carnivorous dietary patterns are associated with greater likelihood of IBD-development in a large prospective population-based cohort
- Genetic evidence of assortative mating in humans
- Skin autofluorescence, a non-invasive biomarker for advanced glycation end products, is associated with the metabolic syndrome and its individual components
- Spousal similarities in cardiometabolic risk factors: A cross-sectional comparison between Dutch and Japanese data from two large biobank studies
- Understanding socioeconomic differences in remitted metabolic syndrome among adults: what is the mediating role of health behaviors?
- Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.
- The Relationship Between Caffeine Intake and Dry Eye Disease
- New Insights in Hidradenitis Suppurativa from a Population-based Dutch Cohort: Prevalence, Smoking Behaviour, Socioeconomic Status and Comorbidities
- Identification of context-dependent expression quantitative trait loci in whole blood
- Dietary intake in the Lifelines cohort study: baseline results from the Flower Food Frequency Questionnaire among 59,982 participants
- Predictors of positive Self Rated Health in persons with tinnitus from the general population
- Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease
- Factors that influence the volatile organic compound content in human breath
- The effect of host genetics on the gut microbiome
- NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality
- The prevalence and severity of hand eczema in the general population: data from the Lifelines Cohort Study.
- Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease
- The association between fast-food outlet proximity and density and Body Mass Index: Findings from 147,027 Lifelines cohort study participants
- Disease variants alter transcription factor levels and methylation of their binding sites
- The influence of proton pump inhibitors and other commonly used medication on the gut microbiota
- The Well-Known Gene HHIP and Novel Gene MECR Are Implicated in Small Airway Obstruction
- Genetic and environmental influences interact with age and sex in shaping the human methylome
- 52 Genetic Loci Influencing Myocardial Mass
- Idéfix: identifying accidental sample mix-ups in biobanks using polygenic scores
- Large HDL particles negatively associate with leukocyte counts independent of cholesterol efflux capacity: A cross sectional study in the populationbased LifeLines DEEP cohort
- Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability
- Increased prevalence of metabolic syndrome in patients with bipolar disorder compared to a selected control group-a Northern Netherlands LifeLines population cohort study
- Fatigue in patients with chronic disease: results from the population‑based Lifelines Cohort Study
- A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency
- Maternal occupational exposure to endocrine-disrupting chemicals and urogenital anomalies in the offspring
- Association between adherence to statin therapy and low-density lipoprotein cholesterol (LDL-c) response in first-time users of standard-dose and low-dose statins: the PharmLines initiative
- Population-based values and abnormalities of the electrocardiogram in the general Dutch population: The Lifelines Cohort Study
- Development and external validation of the "Flower-FFQ": a food frequency questionnaire designed for the Lifelines Cohort Study
- Genomic analysis of diet composition finds novel loci and associations with health and lifestyle
- Hand eczema and lifestyle factors in the Dutch general population: evidence for smoking, chronic stress, and obesity
- CKD Prevalence Varies across the European General Population
- The LifeLines Cohort Study: a resource providing new opportunities for environmental epidemiology
- Sex, BMI and age differences in metabolic syndrome: the Dutch Lifelines Cohort Study
- The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
- Gut microbiota composition associated with stool consistency
- Genome-wide association study on the FEV/FVC-ratio in never-smokers identifies HHIP and FAM13A.
- The impact of the Covid-19 crisis on socioeconomic differences in physical activity behavior: Evidence from the Lifelines COVID-19 cohort study
- Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure
- Automated mass spectrometric analysis of urinary free catecholamines using on-line solid phase extraction.
- Niacin (Vitamin B3) Supplementation in Patients with Serotonin-Producing Neuroendocrine Tumor
- No effect of the Thr92Ala polymorphism of deiodinase-2 on thyroid hormone parameters, health-related quality of life and cognitive functioning in a large population-based cohort study.
- Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD.
- High-density lipoproteins and adrenal steroidogenesis: A population-based study
- Medication use and dry eye symptoms: A large, hypothesis-free, population-based study in the Netherlands
- Motives for withdrawal of participation in biobanking and participants' willingness to allow linkages of their data
- Genetic loci associated with heart rate variability and their effects on cardiac disease risk
- Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility
- Diet quality and incident chronic kidney disease in the general population: The Lifelines Cohort Study
- Occupational Differences in Metabolic Syndrome Incidence and the Role of Health Behaviors in an Aging Workforce
- The vision-related burden of dry eye
- Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs.
- Diet quality indices and gastrointestinal cancer risk: results from the Lifelines study
- Genome-wide CNV investigation suggests a role for cadherin, Wnt, and p53 pathways in primary open-angle glaucoma
- Investigating whether a combination of higher CRP and depression is differentially associated with worse executive functioning in a cohort of 43,896 adults
- Gender differences in the mental health impact of the COVID-19 lockdown: Longitudinal evidence from the Netherlands
- Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index.
- lodGWAS: a software package for genome-wide association analysis of biomarkers with a limit of detection
- Short communication: Genetic association between schizophrenia and cannabis use
- Psychosocial work factors and blood pressure among 63 800 employees from The Netherlands in the Lifelines Cohort Study
- Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
- A Protein Diet Score, Including Plant and Animal Protein, Investigating the Association with HbA1c and eGFR-The PREVIEW Project
- A spatial analysis of dietary patterns in a large representative population in the north of The Netherlands - the Lifelines cohort study
- Discovery of novel heart rate-associated loci using the Exome Chip
- Blood lipids-related dietary patterns derived from reduced rank regression are associated with incident type 2 diabetes
- Long-term exposure to fine particulate matter, lung function and cognitive performance: A prospective Dutch cohort study on the underlying routes
- Investigating whether a combination of higher CRP and depression is differentially associated with worse executive functioning in a cohort of 43,896 adults
- Personality Polygenes, Positive Affect, and Life Satisfaction
- Associations between systemic and local corticosteroid use with metabolic syndrome and body mass index
- Excess mortality in depressive and anxiety disorders: The Lifelines Cohort Study
- The anemia-independent impact of myelodysplastic syndromes on health-related quality of life
- Prevalence of adult atopic dermatitis in the general population, with a focus on moderate to severe disease: results from the Lifelines Cohort Study
- Connecting the dots, genome-wide association studies in substance use
- SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume
- The association of sex, age and FKBP5 genotype with common somatic symptoms: a replication study in the Lifelines Cohort Study
- The trans-ancestral genomic architecture of glycemic traits
- Skin autofluorescence improves the Finnish Diabetes Risk Score in the detection of diabetes in a large population-based cohort: The Lifelines Cohort Study
- A Classification Approach for Cancer Survivors from Those Cancer-Free, Based on Health Behaviors: Analysis of the Lifelines Cohort
- Residential Air Pollution and Associations with Wheeze and Shortness of Breath in Adults: A Combined Analysis of Cross-Sectional Data from Two Large European Cohorts
- Sex and Gender-Related Differences in COVID-19 Diagnoses and SARS-CoV-2 Testing Practices During the First Wave of the Pandemic: The Dutch Lifelines COVID-19 Cohort Study
- Physical activity and 4-year changes in body weight in 52,498 non-obese people: the Lifelines cohort
- The relationship between alcohol consumption and dry eye
- Thyroid function and metabolic syndrome in the population-based LifeLines cohort study
- Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
- Medication use and dry eye symptoms: A large, hypothesis-free, population-based study in the Netherlands
- Understanding importance of clinical biomarkers for diagnosis of anxiety disorders using machine learning models
- Understanding human immune function using the resources from the Human Functional Genomics Project
- Genotype-covariate interaction effects and the heritability of adult body mass index
- Influence of Storage and Inter- and Intra-Assay Variability on the Measurement of Inflammatory Biomarkers in Population-Based Biobanking.
- Prediction of Incident Cancers in the Lifelines Population-Based Cohort
- Understanding socioeconomic differences in incident metabolic syndrome among adults: What is the mediating role of health behaviours?
- A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
- The impact of low education and poor health on unemployment varies by work life stage
- Genetics, Lifestyle, and Low-Density Lipoprotein Cholesterol in Young and Apparently Healthy Women
- Demographic, Lifestyle and Psychosocial Determinants of Heart Rate Variability in the General Population: A Study from the Lifelines Cohort and Biobank
- Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure
- The validity and reliability of a digital Ruff Figural Fluency Test (RFFT)
- Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study.
- Airborne occupational exposures and the risk of developing respiratory symptoms and airway obstruction in the Lifelines Cohort Study
- Seasonal prevalence and characteristics of low-dose CT detected lung nodules in a general Dutch population
- The interaction of genetic predisposition and socioeconomic position with type 2 diabetes mellitus: cross-sectional and longitudinal analyses from the Lifelines Cohort and Biobank Study.
- Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs
- Prevalence of internalizing disorders, symptoms, and traits across age using advanced nonlinear models
- Low Health Literacy is Associated with the Onset of CKD during the Life Course
- The Lifelines Cohort Study: a data source available for studying informal caregivers’ experiences and the outcomes of informal caregiving
- Combining informal care and paid work: The use of work arrangements by working adult-child caregivers in the Netherlands.
- Occupational exposure to pesticides is associated with differential DNA methylation
- Arthritis autoantibodies in individuals without rheumatoid arthritis: follow-up data from a Dutch population-based cohort (Lifelines)
- Patient attitudes towards faecal sampling for gut microbiome studies and clinical care reveal positive engagement and room for improvement
- DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1c levels: a systematic review and replication in a case-control sample of the Lifelines study
- Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort
- Dairy product consumption is associated with pre-diabetes and newly diagnosed type 2 diabetes in the Lifelines Cohort Study
- Separate and combined effects of individual and neighbourhood socio-economic disadvantage on health-related lifestyle risk factors: a multilevel analysis
- Advanced Glycation End-products are associated with Physical Activity and Physical Functioning in the older population
- The long-term genetic stability and individual specificity of the human gut microbiome
- Development and external validation of the "Flower-FFQ": a food frequency questionnaire designed for the Lifelines Cohort Study
- Systematic Evaluation of Corticosteroid Use in Obese and Non-obese Individuals: A Multi-cohort Study
- Predicted values for the forced expiratory flow adjusted for forced vital capacity, a descriptive study
- Grandmaternal smoking, asthma and lung function in the offspring: the Lifelines cohort study
- Dietary Protein Sources and Muscle Mass over the Life Course: The Lifelines Cohort Study
- Pediatric lipid reference values in the general population: The Dutch Lifelines cohort study
- The role of the microbiome for human health: from basic science to clinical applications.
- No association between DNA methylation and COPD in never and current smokers
- Alternative pediatric metabolic syndrome definitions impact prevalence estimates and socioeconomic gradients
- Anthropometrics and metabolic syndrome in relation to glucocorticoid receptor polymorphisms in corticosteroid users
- Physical Activity and Sleep in Chronic Fatigue Syndrome and Fibromyalgia Syndrome: Associations with Symptom Severity in the General Population Cohort LifeLines
- Concordance assessment of self-reported medication use in the Netherlands three-generation Lifelines Cohort Study with the pharmacy database IADB.nl: The PharmLines Initiative
- Familial Aggregation of CKD and Heritability of Kidney Biomarkers in the General Population: The Lifelines Cohort Study
- Association Between Peripheral Blood Cell Count Abnormalities and Health-Related Quality of Life in the General Population
- Skin autofluorescence, a non‐invasive biomarker for advanced glycation end products, is not related to the number of pregnancies.
- Prevalence of sarcopenic obesity and sarcopenic overweight in the general population: The lifelines cohort study
- Determinants of Heart Rate Variability in the General Population: The Lifelines Cohort Study Determinants of Heart Rate Variability
- Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.
- Economic downturns and infant health
- Epigenome-wide association study identifies DNA methylation markers for asthma remission in whole blood and nasal epithelium
- The relationship between dry eye and sleep quality
- Development of the food-based Lifelines Diet Score (LLDS) and its application in 129,369 Lifelines participants.
- Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
- Genome-wide interaction study of gene-by-occupational exposures on respiratory symptoms
- How is sport participation related to mortality, diabetes and prediabetes for different Body Mass Index levels?
- Genetic pre-screening for glaucoma in population-based epidemiology: protocol for a double-blind prospective screening study within Lifelines (EyeLife)
- Ambient air pollution exposure and chronic bronchitis in the Lifelines cohort
- Association of anemia with health-related quality of life and survival: a large population-based cohort study
- Skin autofluorescence of advanced glycation end products and mortality in affective disorders in the lifelines cohort study: A mediation analysis
- Methylmalonic acid, vitamin B12, renal function, and risk of all-cause mortality in the general population: results from the prospective Lifelines-MINUTHE study
- Developing a clinical prediction rule for repeated consultations with functional somatic symptoms in primary care: a cohort study
- Exposure to disinfection byproducts and risk of type 2 diabetes: a nested case-control study in the HUNT and Lifelines cohorts
- Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis
- Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
- Scalp hair cortisol and testosterone levels in patients with sarcoidosis
- Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
- Impact of Drug-Gene-Interaction, Drug-Drug-Interaction, and Drug-Drug-Gene-Interaction on (es)Citalopram Therapy: The PharmLines Initiative
- Physical Activity, Fatty Liver, and Glucose Metabolism Over the Life Course: The Lifelines Cohort
- Hair cortisol-a method to detect chronic cortisol levels in patients with Prader-Willi syndrome
- Female sex and femininity independently associate with common somatic symptom trajectories
- Nutrition beyond the first 1000 days: diet quality and 7-year change in BMI and overweight in 3-year old children from the Dutch GECKO Drenthe birth cohort
- Offspring Birth Weight Is Associated with Specific Preconception Maternal Food Group Intake: Data from a Linked Population-Based Birth Cohort
- Low body weight and involuntary weight loss are associated with Raynaud's phenomenon in both men and women
- Variance Components Models for Analysis of Big Family Data of Health Outcomes in the Lifelines Cohort Study
- Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases
- Occupational exposures and genetic susceptibility to occupational exposures are related to sickness absence in the Lifelines cohort study
- Development and validation of a LC-MS/MS method for the establishment of reference intervals and biological variation for five plasma steroid hormones
- Epidemiology of thyroid disorders in the Lifelines Cohort Study (the Netherlands)
- Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
- The neuroactive potential of the human gut microbiota in quality of life and depression
- Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies novel loci associated with serum lipids
- Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
- Statins and non‐alcoholic fatty liver disease
- Improving the Measurement of Functional Somatic Symptoms With Item Response Theory
- Genome-wide associaton scan of serum urea in European populations identifies two novel loci
- Circulating fatty acids as biomarkers of dairy fat intake: Data from the Lifelines Biobank and Cohort Study
- Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
- Associations between preconception macronutrient intake and birth weight across strata of maternal BMI
- Active smoking and macrocytosis in the general population: Two population‐based cohort studies
- Maternal occupational exposure and congenital heart defects in offspring
- Hair glucocorticoids as biomarker for endogenous Cushing's syndrome: validation in two independent cohorts
- The relationship between occupation and dry eye
- Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
- The Lifelines COVID-19 Cohort: a questionnaire-based study to investigate COVID-19 infection and its health and societal impacts in a Dutch population-based cohort
- Transnational access to large prospective cohorts in Europe: Current trends and unmet needs
- Gallstones, Body Mass Index, C-reactive Protein and Gallbladder Cancer – Mendelian Randomization Analysis of Chilean and European Genotype Data
- Structural variation in the gut microbiome associates with host health
- Airborne occupational exposures and inflammatory biomarkers in the Lifelines cohort study
- Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
- Personality as a Resource for Labor Market Participation among Individuals with Chronic Health Conditions
- High-pitch dual-source CT for coronary artery calcium scoring: A head-to-head comparison of non-triggered chest versus triggered cardiac acquisition
- Development and Interlaboratory Validation of Two Fast UPLC–MS-MS Methods Determining Urinary Bisphenols, Parabens and Phthalates
- Translation and validation of the Volunteer Functions Inventory (VFI) among the Dutch general older population
- Comparison of two methods for the assessment of intra-erythrocyte magnesium and its determinants: Results from the LifeLines cohort study
- Skin autofluorescence of advanced glycation end products and course of affective disorders in the lifelines cohort study, a prospective investigation
- Phenome-wide association analysis of LDLcholesterol lowering genetic variants in PCSK9
- Autonomic Dysfunction and Blood Pressure in Glaucoma Patients: The Lifelines Cohort Study
- Development and Validation of a Web-Based Questionnaire to Identify Environmental Risk Factors for Inflammatory Bowel Disease: The Groningen IBD Environmental Questionnaire (GIEQ)
- The influence of unhealthy behaviours on early exit from paid employment among workers with chronic diseases: a prospective study using the Lifelines cohort
- Intestinal microbiome composition and its relation to joint pain and inflammation
- A catalog of genetic loci associated with kidney function from analyses of a million individuals
- Trust in Centralized Large-Scale Data Repository: A Qualitative Analysis
- Folate reference interval estimation in the Dutch general population
- The mediating role of unhealthy behaviors and body mass index in the relationship between high job strain and self-rated poor health among lower educated workers
- Hair Cortisol Concentrations in Chronic Central Serous Chorioretinopathy
- Do Cesarean Delivery rates rise when the economy declines? A test of the economic stress hypothesis
- Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits
- Elevated rates of autism, other neurodevelopmental and psychiatric diagnoses, and autistic traits in transgender and gender-diverse individuals
- Intraregional differences in renal function in the Northern Netherlands: The Lifelines Cohort Study
- Age- And Sex-Specific Analyses of Diet Quality and 4-Year Weight Change in Nonobese Adults Show Stronger Associations in Young Adulthood
- Vitamin Status and Diet in Elderly with Low and High Socioeconomic Status: The Lifelines-MINUTHE Study
- Heritability and the Genetic Correlation of Heart Rate Variability and Blood Pressure in >29 000 Families The Lifelines Cohort Study
- The association of multimorbidity within cardio-metabolic disease domains with dietary patterns: A cross-sectional study in 129 369 men and women from the Lifelines cohort.
- Demographic and prosocial intrapersonal characteristics of biobank participants and refusers: the findings of a survey in the Netherlands
- Assessing causal relationship from gut microbiota to heel bone mineral density
- Impact of road traffic noise on obesity measures: Observational study of three European cohorts
- Glaucoma in large-scale population-based epidemiology: a questionnaire-based proxy
- Validating the doubly-weighted genetic risk score for the prediction of 1 type 2 diabetes in the Lifelines and Estonian Biobank cohorts
- Identification of environmental risk factors associated with the development of Inflammatory Bowel Disease
- A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease
- Motives of contributing personal data for health research: (non-)participation in a Dutch biobank
- Relationship between gut microbiota and circulating metabolites in population-based cohorts
- Lifestyle components: Self-reported physical activity, nutritional status, sleep quality and incident atrial fibrillation
- Prevalence and Risk Factors of Dry Eye in 79,866 Participants of the Population-Based Lifelines Cohort Study in the Netherlands
- Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression.
- Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes
- Phenotypic and functional translation of IL33 genetics in asthma
- Dietary Patterns Based on Estimated Glomerular Filtration Rate and Kidney Function Decline in the General Population: The Lifelines Cohort Study
- Comparison of health behaviours between cancer survivors and the general population: a cross-sectional analysis of the Lifelines cohort
- Sex‐Based Differences in Unrecognized Myocardial Infarction
- The neighbour’s effect on well-being: how local relative income differentials affect resident's subjective well-being
- Systemic and local corticosteroid use is associated with reduced executive cognition, and mood and anxiety disorders
- Assessment of Diet Quality and Adherence to Dietary Guidelines in Gastrointestinal Cancer Survivors: A Cross-Sectional Study
- DNA methylation is associated with lung function in never smokers
- Arthritis autoantibodies in individuals without rheumatoid arthritis: Follow up data from a Dutch population-based cohort (Lifelines)
- Relation Between Leisure Time, Commuting, and Occupational Physical Activity With Blood Pressure in 125 402 Adults: The Lifelines Cohort
- Description and determinants of the faecal resistome and microbiome of farmers and slaughterhouse workers: a metagenome-wide cross-sectional study
- ABCB1/4 Gallbladder Cancer Risk Variants Identified in India Also Show Strong Effects in Chileans
- Predictors of New Onsets of Irritable Bowel Syndrome, Chronic Fatigue Syndrome and Fibromyalgia: The Lifelines Study
- Dairy shows different associations with abdominal and BMI-defined overweight: Cross-sectional analyses exploring a variety of dairy products
- Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci
- The Dutch Comparative Scale for Assessing Volunteer Motivations among Volunteers and Non-Volunteers: An Adaptation of the Volunteer Functions Inventory.
- Association between skin autofluorescence of advanced glycation end products and affective disorders in the lifelines cohort study
- Likely Questionnaire-Diagnosed Food Allergy in 78, 890 Adults From the Northern Netherlands
- The Role of Self-Regulation in the Effect of Self-Tracking of Physical Activity and Weight on BMI
- Arsenic and gallbladder cancer risk: Mendelian randomizationanalysis of European prospective data
- Dyadic Associations between Physical Activity and Body Mass Index in Couples in which One Partner has Diabetes: Results from the Lifelines Cohort Study
- Protein Intake and the Incidence of Pre-Diabetes and Diabetes in 4 Population-Based Studies: The PREVIEW Project
- Cohort Profile: The Dutch Perined-Lifelines birth cohort
- Where did inaction go? Towards a broader and more refined perspective on collective actions
- Binning Unassembled Short Reads Based on K-Mer Abundance Covariance Using Sparse Coding
- Gender Differences in Developing Biomarker-Based Major Depressive Disorder Diagnostics
- Improving Diagnosis of Depression With XGBOOST Machine Learning Model and a Large Biomarkers Dutch Dataset (n = 11,081)
- The genetic architecture of sporadic and recurrent miscarriage
- Lifelines Next – a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study
- Duality of Tocopherol Isoforms and Novel Associations With Vitamins Involved in One-Carbon Metabolism: Results From an Elderly Sample of the LifeLines Cohort Study
- Gender and sex independently associate with common somatic symptoms and prevalence of chronic disease
- Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals
- Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium
- Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution.
- Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics
- SNP-Based Heritability Estimates of Common and Specific Variance in Self- and Informant-Reported Neuroticism Scales.
- Higher skin autofluorescence in individuals at risk for rheumatoid arthritis: results from a large population based cohort.
- The decreasing prevalence of ADHD across the adult lifespan confirmed
- The effect of extended participation windows on attendance at cervical cancer screening
- Stress-related exposures amplify the effects of genetic susceptibility on depression and anxiety
- Socioeconomic Inequalities in pediatric Metabolic Syndrome: mediation by parental health literacy
- The decreasing prevalence of ADHD across the adult lifespan confirmed
- The effect of extended participation windows on attendance at cervical cancer screening
- Higher skin autofluorescence in individuals at risk for rheumatoid arthritis: results from a large population based cohort.
- The decreasing prevalence of ADHD across the adult lifespan confirmed
- The effect of extended participation windows on attendance at cervical cancer screening
- Duplicaat van The decreasing prevalence of ADHD across the adult lifespan confirmed
- Effects of Platelet Count on Blood Pressure: Evidence from Observational and Genetic Investigations
- Metabolic syndrome and poor self-rated health as risk factors for premature employment exit: A longitudinal study among 55,016 middle-aged and older workers
- Metabolic syndrome in adults with autistic traits: associated psychological, behavioural, and biological factors in females and males
- Fibroblast growth factor 23 and calcium-phosphate 2 metabolism in patients with type 1 diabetes
- Diet and physical activity as risk-reducing factors for hidradenitis suppurativa
- A genome-wide association study of 24-hour urinary excretion of endocrine disrupting chemicals
- Effects of endocrine disrupting chemicals and their interactions with genetic risk scores on cardiometabolic traits
- Sarcopenia augments the risk of excess weight on COVID-19 hospitalization: a prospective study using Lifelines COVID-19 Cohort
- Mapping insomnia symptoms and circadian preferences to mental health problems in men and women across the lifespan
- Genetic Correlates of Biological Aging and the Influence on Prediction of Mortality
- Hand eczema-related presenteeism and sickness absence: A cross-sectional population-based study
- Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation
- Physical Activity Levels, Correlates, and All-Cause Mortality Risk in People Living With Different Health Conditions
- Lifestyle, health and quality of life of older adults after coronavirus infection: a longitudinal cohort study
- Transmission and dynamics of mother-infant gut viruses during pregnancy and early life
- Genomics research of lifetime depression in the Netherlands: The BIObanks Netherlands Internet Collaboration (BIONIC) project
- Childhood maltreatment and the risk of impaired glucose metabolism or type 2 diabetes in young adults: findings from the Lifelines Cohort Study
- Long-term glucocorticoid exposure and incident cardiovascular diseases - the Lifelines cohort
- Educational inequalities in major depressive disorder prevalence, timing and duration among adults over the life course: a microsimulation analysis based on the Lifelines Cohort Study
- Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
- Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
- Who is at risk of lung nodules on low-dose CT in a Western country? A population-based
- Effect of emphysema on AI software and human reader performance in lung nodule detection from low-dose chest CT
- The association of Obesogenic Environments with Weight Status, Blood Pressure, and Blood Lipids: A Cross-Sectional Pooled Analysis across Five Cohorts
- Skin autofluorescence, a measure for accumulation of advanced glycation end products, positively associates with blood neutrophil and monocyte counts in the general population,
- Low-Dose CT–derived Bronchial Parameters inIndividuals with Healthy Lungs
- Persistent physical symptoms: definition, genesis, and management
- Multi-ancestry polygenic risk scores for venous thromboembolism
- Does social need fulfillment moderate the association between socioeconomic status and health risk behaviours during pregnancy?
- Exposome-Wide-Association-Study of body mass index (BMI) using a novel meta-analytical approach for random forest models
- A genome-wide association study of hand eczema identifies locus 20q13.33 and reveals genetic overlap with atopic dermatitis
- The LifeLines cohort study: prevalence of tinnitus associated suffering and behavioral outcomes in children and adolescents. Running title: Tinnitus in children
- Markers of imminent myocardial infarction
- Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content
- Multiple estimates of the Frisian and Low Saxon speaker population size in the Netherlands
- Metabolic Syndrome Status Changes and Cognitive Functioning: Insights from the Lifelines Cohort Study
- Minority language happiness: the link between social inclusion, well-being, and speaking a regional language in the northern Netherlands
- Higher levels of markers for early atherosclerosis in anti-citrullinated protein antibodies positive individuals at risk for RA, a cross sectional study
- Comorbidity and sex differences in functional disorders and internalizing disorders
- Mediation by parent health literacy and behaviour of socioeconomic inequality in child overweight
- New insights into the paradox between smoking and the risk of SARS-CoV-2 infection (COVID-19): insufficient evidence for a causal association
- Role of Inflammation in Depressive and Anxiety Disorders, Affect, and Cognition: Genetic and Non-Genetic Findings in the Lifelines Cohort Study
- Leveraging FHIR in Federated Learning Environments: A Data Harmonization Framework for Cohort Studies
- Association between diet quality and all-cause mortality in a large Dutch cohort
- Urinary Free Glycosaminoglycans Identify Adults at High Risk of Developing Early-stage High-grade Bladder Cancer
- Association between skin autofluorescence and coronary calcification in the general population
- Genome-wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125,393 individuals
- Connecting the dots: Network structures of internalizing and functional symptoms
- Eczema in early childhood increases the risk of allergic multimorbidity
- The association between wet work and hand eczema in the Dutch general population: Application of a job exposure matrix to the lifelines cohort study
- The effect of diabetes in the multifaceted relationship between education and cognitive function
- Association of Cardiovascular Risk Scores with Migraine Status
- Insights into hair dye use and self-reported adverse skin reactions in the Dutch general population: a cross-sectional questionnaire-based study
- Educational and income inequalities across diseases in Denmark: a register-based cohort study
- Genetic Architecture Reconciles Linkage and Association Studies of Complex Traits
- The role of leukocytes in cognitive impairment due to long-term exposure to fine particulate matter: A large population-based mediation analysis
- The association of overweight, obesity, and long-term obesity with SARS-CoV-2 infection: a meta-analysis based on 9 population-based cohorts
- Intergenerational language transmission of Frisian and Low Saxon in the Netherlands
- Analysis of microbial composition and sharing in low-biomass human milk samples: a comparison of DNA isolation and sequencing techniques
- Coffee consumption and risk of kidney function decline in a Dutch population-based cohort
- Lifestyle factors and incident multimorbidity related to chronic disease: a population-based cohort study
- Prevalence and determinants of metabolic syndrome in 2338 childhood cancer survivors: A Dutch Childhood Cancer Survivor LATER 2 study
- Simplifying coronary artery disease risk stratification: development and validation of a questionnaire-based alternative comparable to clinical risk tools
- The association of multidimensional frailty with metabolic syndrome and low-grade inflammation in community-dwelling older adults in the Netherlands: a Lifelines cohort study
- A retrospective study of the MDS criteria for prodromal Parkinson's disease in the general population
- Positive and negative affect, related mental health traits, and cognitive performance: shared genetic architecture and potential causality
- Shared genetic architecture and causality between autism spectrum disorder and irritable bowel syndrome, multisite pain, and fatigue
- The mechanisms underlying the intergenerational transmission of substance use and misuse: An integrated research approach
- The contribution of attention-deficit/hyperactivity disorder polygenic load to metabolic and cardiovascular health outcomes: a large-scale population and sibling study
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