Deelnemers

Heb je een vraag? Neem gerust contact met ons op.

 

Telefoon: 050 - 36 11 113 (werkdagen van 8.00 - 17.00 uur)

Contactformulier

Researchers

Do you have a question regarding working with Lifelines? Please contact us, we're happy to help you.

Contact us

Pers

We voorzien media graag van informatie en we behandelen graag verzoeken voor interviews, opnames en beeldmateriaal.

Stuur een e-mail

Contact

Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits.

Effective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors. We used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell populations in peripheral blood, including associations with immunoglobulin concentrations, from ∼500 healthy volunteers from the Human Functional Genomics Project. Genetic heritability estimation showed that variations in T cell numbers are more strongly driven by genetic factors, while B cell counts are more environmentally influenced. Quantitative trait loci (QTL) mapping identified eight independent genomic loci associated with leukocyte count variation, including four associations with T and B cell subtypes. The QTLs identified were enriched among genome-wide association study (GWAS) SNPs reported to increase susceptibility to immune-mediated diseases. Our systems approach provides insights into cellular and humoral immune trait variability in humans.

Year of publication

2016

Journal

Cell Rep.

Author(s)

Aguirre-Gamboa, R
Joosten, I
Urbano PC et al.

Full publication

Click here to view the full publicationClick here to view the full publication

Tags