Sex specific mediators of sleep disturbance effects on brain function

Sleep disturbances impact both physiological and psychological functions, leading to decreased well-being through cognitive impairment, mood alterations, and compromised health parameters. They frequently co-occur with neuropsychiatric conditions, exacerbating their severity or precipitating initial episodes. Nonetheless, individual differences influence susceptibility to specific consequences of sleep disruptions. Our research aims to understand the influence of diverse factors—such as genetic predisposition, sex-specific variables, and lifestyle choices—on the neurobiological consequences of sleep disturbances. Through this investigation, we seek to elucidate mechanisms underlying the effect that sleep disturbances have on the brain, and consequently on cognition, mood, and overall heath.