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Using Data on Biomarkers and Siblings to Study Early-Life Economic Determinants of Type-2 Diabetes

We study the effect of economic conditions early in life on the occurrence of type-2
diabetes in adulthood using contextual economic conditions and within-sibling pair
variation. We use data from Lifelines: a longitudinal cohort study and biobank
including 51,270 siblings born in the Netherlands from 1950 onward. Sibling fixedeffects account for selective fertility. To identify type-2 diabetes we use biomarkers
on the hemoglobin A1c concentration and fasting glucose in the blood. We find
that adverse economic conditions around birth increase the probability of type-2
diabetes later in life both in males and in females. Inference based on self-reported
diabetes leads to biased results, wrongly suggesting the absence of a relationship
between early-life conditions and type-2 diabetes later in life. The same applies to
inference that does not account for selective fertility.

Year of publication

2025

Journal

Health economics

Author(s)

Alessie, R.J.M.
Angelini, V.
van den Berg, G.J.
Mierau, J.O.
Niccodemi, G.

Full publication

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